Postdoctoral Fellow - Antibody and Protein Engineering, Nanobody

A postdoctoral fellow position is available immediately in the Antibody Engineering Program (AEP) under Dr. Mitchell Ho at the Center for Cancer Research (CCR), National Cancer Institute (NCI) in Bethesda, Maryland, USA.

Single-domain antibodies (also known as ‘nanobodies’) have the ability to reach buried sites, modulate protein structures, and are small and easily expressed in bacteria and mammalian cells. These features make them attractive for incorporating into cancer therapeutics such as CAR T cells and bispecific antibodies. Dr. Ho’s laboratory at the NCI constructed large phage-displayed shark and camel nanobody libraries. Postdoctoral fellows at the AEP are expected to receive training and make methodological and technological advances in antibody engineering and therapeutics for treating cancer and viral infections in a highly collaborative research environment.

Candidates are expected to have completed, or be completing, a Ph.D. or M.D./Ph.D. with a strong publication record in biochemistry. Highly motivated candidates who are interested in innovative, high-impact basic and translational research are encouraged to apply. A research background in biochemistry, molecular biology, immunology, and/or microbiology is required. Experience with protein structure and/or computational skills is a plus.

The NIH is dedicated to building a community in its training and employment programs and encourages the application and nomination of qualified women, minorities, and individuals with disabilities.