Postdoctoral Fellow - Chemical Biology/Molecular Pharmacology
National Center for Advancing Translational Sciences, Bethesda, MD and surrounding area
About the position
NCATS, a major translational research component of NIH, seeks applications from qualified candidates to fill a post-doctoral fellowship position within the Assay Development and Screening Technology laboratory (ADST) of Dr. James Inglese within the Division of Preclinical Innovation (DPI). The DPI is home to approximately 230 biologists, medicinal chemists, and computational scientists who work on a broad portfolio of preclinical drug discovery projects, as well as programs that involve the development of innovative new technologies to enable the acceleration of biomedical research.
The ADST laboratory is interested in the discovery and development of novel molecular modalities for a variety of therapeutic indications, including cancer, with particular emphasis on rare metabolic disease applications. The current focus centers on the evaluation of antifolate-based proteolysis targeting chimera (PROTAC) chemical libraries to define target profiles and underlying mechanisms of action. This research will involve the design and implementation of CRSIPR/Cas9 genome edited reporter cell lines to interrogate the molecular pharmacology and biochemical network of one-carbon metabolism using these chemical libraires. Compounds of interest will be characterized using proteomics and metabolomics analysis and depending on their properties assessed in synthetic lethality functional genomics and conditional combination drug screens. Candidate molecules displaying novel pharmacology will enter a collaborative therapeutic development program involving medicinal chemistry optimization accompanied by relevant in vivo cancer and/or relevant models associated with rare disorders. This position is available beginning Spring 2024.
Recent research from this laboratory relevant to the position can be found at: https://www.cell.com/cell-chemical-biology/fulltext/S2451-9456(23)00333-1
For more information about the lab see: https://www.youtube.com/watch?v=VxtpySnbX-c and https://ncats.nih.gov/staff/jinglese
The successful applicant will have the opportunity to use an interdisciplinary approach to pursue research interests as they advance to an independent research career in the supportive intramural environment of the NCATS labs in Rockville, Md, which also includes core facilities specializing in automated high throughput screening, synthetic organic chemistry, functional genomics, proteomics, advanced microscopy, biochemistry, human iPS cells and chem/bioinformatics.
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What you'll need to apply
Applications from women, minorities and persons with disabilities are strongly encouraged. Applicants should send their curriculum vitae and a brief statement of research interests/career goals, and request 3 letters of reference addressed to Dr. J. Inglese to be sent via email to: NCATS2024Postdoc@mail.nih.gov
Candidates must have obtained a Ph.D. or M.D. degree (within the past 5 years) with background in Chemical Biology. The ideal candidate should have a strong cellular or chemical biology background with accomplishments demonstrated by first-author publications in peer reviewed journals.
HHS and NIH are Equal Opportunity Employers