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Postdoctoral Fellow - Gene Regulation and Cytokine Biology in Neurodegeneration and Neuroinflammation

National Eye Institute, Bethesda, MD and surrounding area

About the position

The laboratory of Dr. Han-Yu Shih at the National Institutes of Health (NIH) in Bethesda, MD is seeking a motivated and talented postdoctoral researcher to join our multidisciplinary team. Our lab focuses on understanding the mechanisms that precisely regulate gene expression in lymphoid cells, with a particular interest in homeostasis and CNS inflammation. We use cutting-edge genomic approaches to address two fundamental questions:

  1. How do cytokines and their producers contribute to the progression of neurodegenerative and neuroinflammatory diseases, such as Alzheimer’s disease?
  2. How does crosstalk between neural and immune cells control autoimmune diseases in CNS?

The successful candidate will use “omic” approaches to investigate immunoregulation and identify potential therapeutic targets. You will have the opportunity to lead and co-lead projects, design experiments for generating high-dimensional data (single cell transcriptomes and epigenomes, spatial transcriptomes, TCR/BCR repertoires), and work closely with collaborators and lab members. Additionally, you will receive training in bioinformatics and have opportunities to mentor postbacs or summer students. will be available based on interest. Salary is commensurate with research experience and accomplishments.

Apply for this vacancy

What you'll need to apply

Interested candidates please send a cover letter, curriculum vitae, and contact information of three references to:

Contact name

Han-Yu Shih

Contact email


We are seeking highly motivated candidates who meet the following requirements:

  • Hold a Ph.D. or M.D./Ph.D. in immunology, neuroscience, genetics, molecular biology, biochemistry, computational biology or a related field, awarded within the last three years;
  • Have first authorship on at least one peer-reviewed publication;
  • Possess self-motivation and a strong desire to develop and learn cutting-edge technologies and genomic data analysis;
  • Preferred experience in animal experiments or NGS data analysis;
  • Encouraged experience in spatial transcriptomics;
  • Ability to work collaboratively within a highly cohesive group is important.

If you meet these qualifications and are excited about joining a dynamic team working to uncover the mechanisms of lymphoid cell regulation and CNS inflammation using state-of-the-art genomic approaches, we encourage you to apply for this postdoctoral position."

Additional Information

The NIH is dedicated to building a community in its training and employment programs and encourages the application and nomination of qualified women, minorities, and individuals with disabilities.