Skip to Content

Staff Scientist- RAS Pathway Signaling and Design of Novel Therapeutic Approaches

National Cancer Institute, Frederick, Maryland

Position Description:

The Cellular Growth Mechanisms Section (CGMS), Laboratory of Cell and Developmental Biology (LCDS), Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Department of Health and Human Services (DHHS) is recruiting a Staff Scientist in Frederick, Maryland. The position supports scientific efforts in the analysis of RAS pathway signaling and the design of novel therapeutic approaches to treat aberrant RAS signaling in human disease states.

The successful applicant will work in a dynamic and collaborative environment with an extensive network of intramural and extramural researchers. We envision that the staff scientist will contribute substantially to project design, supporting the needs of the CGMS. Duties will include the design of mechanistic studies to investigate the regulation of the RAF kinases and RAS pathway signaling, structural analysis of RAS pathway components, assay development and drug screening, project management for in vivo preclinical studies, and manuscript and grant preparation. An essential skill for the candidate will be to keep abreast of the “state-of-the-art” approaches to study cell signaling and RAS biology in normal and disease states, and to incorporate these new approaches, techniques, and ideas into the CGSM research program.

For additional information about the CGSM, please visit
About NCI's Center for Cancer Research
The Center for Cancer Research is an intramural research component of the National Cancer Institute. CCR’s enabling infrastructure facilitates clinical studies at the NIH Clinical Center, the world’s largest dedicated clinical research complex; provides extensive opportunities for collaboration; and allows scientists and clinicians to undertake high-impact laboratory- and clinic-based investigations. Investigators are supported by a wide array of intellectual, technological, and research resources. For an overview of CCR, please visit


Candidates should have substantial documented expertise in cell signaling, tumor biology, drug screening, and structural biology. The staff scientist recruited will need to demonstrate:

  • full expertise in various molecular biology techniques, including DNA cloning and site-directed mutagenesis;
  • full expertise in various biochemical and cell biological assays, including affinity tagging, protein purification, immunoprecipitation, western blotting, cell culture, and high resolution, live-cell imaging;
  • proficiency in evaluating protein-protein interactions;
  • experience in the structural analysis of protein complexes;
  • skill in the design and execution of high-throughput drug screening and other drug discovery approaches; and
  • the ability to prepare manuscripts and reports.

This position requires that the candidate has extensive post-doctoral training and is able to demonstrate significant knowledge of the research area and current state of the field.

The successful applicant will also manage and mentor other staff members, write reports on completed projects, and be capable of planning future directions in an independent fashion. Applicants should hold a Ph.D. or equivalent doctoral degree, as well as a strong record of publications that demonstrate their skill and expertise.

Salary is commensurate with education and experience. A full benefits package is available, including retirement, health insurance, life insurance, long-term care insurance, annual and sick leave, and Thrift Savings Plan (401K equivalent). This position is not restricted to U.S. citizens.

To Apply:

Please send cover letter, curriculum vitae, statement of research interest and the names and contact information for three references to Jenny May, NCI Administrative Officer at

Applications must be received on or before February 6th 2023 for consideration.

This position is subject to a background investigation. The NIH is dedicated to building a diverse community in its training and employment programs.