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Staff Scientist - High-Throughput Genetics

National Human Genome Research Institute, Bethesda, Maryland

Position Description:

The National Human Genome Research Institute (NHGRI), within the National Institutes of Health (NIH), is seeking exceptional candidates for a Staff Scientist position. The position is in the Systems Biology and Genome Engineering Section (SBGE) of NHGRI’s Intramural Research Program. SBGE’s focus is on genome functionalization: understanding how genetic differences across the genome affect phenotypes. To tackle this question, researchers in SBGE develop and apply new high-throughput genetic methods. This includes harnessing the strengths of CRISPR, large scale oligo synthesis, and yeast genetics. Using these techniques, the staff scientist will be leading a project to comprehensively test the effect of genetic variants in disease genes of interest. The staff scientist’s role will involve both wet lab and dry lab expertise.


Expertise in computational analysis:

  • Fully comfortable using R or Python for data analysis
  • Fully comfortable performing appropriate statistical analyses
  • Expertise to the level of being able to train others

Expertise in molecular biology techniques:

  • Cloning and related molecular genetic approaches
  • Design and troubleshooting of experimental methods
  • Expertise to the level of being able to train others

Scientific independence:

  • Independently design experiments or projects
  • Build a command of the literature
  • Write manuscripts

Applicants should hold a Ph.D. or equivalent doctoral degree, as well as a strong record of publications that demonstrate their skill and expertise.

The ideal candidate will have molecular biology experience in yeast genetics, CRISPR, and/or high-throughput genetic screens, and computational experience analyzing next-generation sequencing data and/or experience with computing clusters such as Biowulf.

To Apply:

Applicants should send curriculum vitae and letter of interest to Meru Sadhu,, and arrange for three letters of recommendation to be sent as well.

Salary will be commensurate with education and experience. A full benefits package is available, including retirement, insurance, and leave benefits.

The NIH is dedicated to building a community in its training and employment programs and encourages the application and nomination of qualified women, minorities, and individuals with disabilities.