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Facility Head: Confocal Microscopy Core Facility

National Cancer Institute, Bethesda, Maryland

Position Description:
The Laboratory of Cancer Biology and Genetics (LCBG), Center for Cancer Research (CCR), NCI, NIH, HHS is looking for a motivated and skilled microscopist to fill a Facility Head position to lead its Confocal Microscopy Core Facility. The CCR Microscopy Core provides microscopy equipment and support to approximately 150 active users representing over 20 NCI laboratories. The Core places an emphasis on training independent users, but the staff is available to assist in all phases of experiments. This includes experimental design, data acquisition, and data analysis. The Core provides state-of-the-art microscopic analyses to better understand critical biological structures and cellular processes involved in cancer.

The Facility Head will also be expected to participate in the CCR Microscopy Core meetings and to interact extensively with the other microscopy facilities in CCR. Light microscopic techniques and analytic methods currently used in this facility include, but are not limited to: 1) co-localization of fluorescent fusion proteins with organelles; 2) demonstration of membrane ruffling, cytoskeletal organization, focal adhesions and other cell morphology; 3) live time-lapse translocation of fluorescent fusion proteins; 4) fluorescent indicators of oxidative stress in live cells; 5) 4D imaging of cell division; 6) Super-Resolution imaging; 7) tiling; 8) Fluorescent Recovery After Photobleaching (FRAP) and Fluorescent Resonance Energy Transfer (FRET); 9) Fluorescence Correlation Spectroscopy (FCS); 10) Fluorescence Lifetime Imaging (FLIM); and, 11) Second Harmonic Generation imaging (SHG) of whole live tissue/organ. The Facility's equipment includes a Zeiss LSM 710 NLO for two-photon imaging, a Zeiss LSM 780 for higher sensitivity imaging, a Zeiss LSM 780/ELYRA for super-resolution imaging of fixed cells, and the Zeiss LSM 880/Airyscan for super-resolution imaging of live and fixed cells.

The Center for Cancer Research (CCR) is an intramural research component of the National Cancer Institute (NCI). CCR contains both basic and clinical research groups on three campuses near Washington DC. Our scientists work on a wide spectrum of biological and biomedical problems and are expected to explore the most important questions in the field of cancer research and treatment. Our enabling infrastructure allows investigators to pursue difficult, high-risk programs; provides extensive opportunities for collaboration; and allows scientists and clinicians to undertake high-impact laboratory- and clinic-based investigations. For an overview of CCR, please visit http://ccr.cancer.gov/. For an overview of the Microscopy Cores and LCBG Core please visit: https://confocal.cancer.gov/cores/.

Requirements:
Applicants must possess a Ph.D. in the biological sciences and extensive experience in state-of-the art-microscopy. The ideal candidate should possess organizational and management skills as well as excellent interpersonal skills for working with users and supervising Core staff. An ongoing and active interest in the latest developments in the microscopy field is desired. This position does not require independent research. The Core staff obtains publications in collaboration with users of the Core.

Review of applications will begin on or about November 15, 2017, but applications will be accepted until the position is filled. Salary is competitive and will be commensurate with the candidate's experience. A full benefits package is available, including retirement, health insurance, life insurance, long-term care insurance, annual and sick leave, and a Thrift Savings Plan (401K equivalent). This position is not restricted to U.S. citizens.

To Apply:
Interested applicants should submit:

  • Curriculum vitae
  • Complete bibliography
  • Names and contact information of three references
  • Summary of research experience

Applications must be submitted electronically to: https://irp-positions.nih.gov/job/facilityhead

For more information contact Lori Holliday at hollidal@mail.nih.gov

This position is subject to a background investigation. The NIH is dedicated to building a diverse community in its training and employment programs. HHS, NIH, and NCI are Equal Opportunity Employers