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Scientist, Immunology

Intrexon, Germantown, Maryland

Position Description:
We are seeking a highly motivated and creative research Scientist, Immunology to join Intrexon's Immunology Division in Germantown, MD. This exciting opportunity will focus on autoimmune diseases and involves extensive hands-on experimental immunology. The successful candidate will have a strong background in immunology, characterization of T cells and autoimmune diseases. The successful candidate will have an in-depth understanding of T cell biology and significant experience with characterizing pathogenic or regulatory T cell phenotype and functionality.

Duties:

  • Set up the evaluation strategy using in vitro studies with human or mouse T cells and in vivo murine models to test novel adoptive T cell therapies.
  • Perform correlative studies to evaluate the transfer, persistence and function of antigen-specific T cells in human clinical trials of adoptive T cell immunotherapy. 
  • Utilize appropriate technology, i.e. Outlook, PowerPoint, and other programs to create and distribute reports and key information.
  • Coordinate parallel tasks across multiple projects, demonstrating prioritization to manage timelines and deliverables.
  • Interpret and effectively execute upon a variety of instructions provided in written, oral, diagram or schedule formats.

Education and Experience:

  • Ph.D. in Immunology, Cellular Biology or Molecular Biology
  • Three (3) or more years post-doctoral experience in academia or industry
  • Proficient in primary immune cell isolation from tissues and in primary tissue culture techniques; hands-on experience with mouse disease models (autoimmune, GVHD or cancer) is preferred
  • Demonstrated experience in the following techniques or tools:
  1. Cellular Immunology: Functional cell based assays (proliferation, T cell activation, Treg suppression), multi-color flow cytometry, cytokine analysis (intracellular, ELISA, Luminex), CD4 T cell subset differentiation and analysis
  2. Molecular biology: electroporation and viral transduction of immune cells, qRT-PCR, Western blot
  3. Software: FlowJo, FACSDiva, statistical analysis (e.g. GraphPad Prism), Microsoft Office

Key Competencies:

  • Ability to understand and execute on the company's mission and values
  • Foster innovation through creative solutions
  • Enjoy working as a member of a dynamic multidisciplinary team in an entrepreneurial environment
  • Basic understanding of statistics, data analysis, and assessment of reproducibility and reliability of experimental data
  • Ability to organize, interpret and communicate complex data sets and project updates in a clear and concise manner to key stakeholders
  • Possess positive interpersonal skills including conflict resolution, with the ability to interact with individuals from a variety of levels and function
  • Maintain a high degree of ethical standard and trustworthiness
  • Capable of fostering change in an organization
  • Energized by accomplishments and excellence in the workplace

Intrexon Corporation (NYSE: XON) is a leader in synthetic biology focused on collaborating with companies in Health, Food, Energy, Environment, and Consumer Sectors to create biologically-based products that improve the quality of life and the health of the planet. Through the company's proprietary UltraVector® platform and suite of technologies, Intrexon provides its partners with industrial-scale design and development of complex biological systems. The UltraVector® platform delivers unprecedented control over the quality, function, and performance of living cells. We call our synthetic biology approach and integrated technologies Better DNA®, and we invite you to discover more at www.DNA.com.

To Apply:
For more information and to apply, please contact Kristy Bucciero Associate Director, Recruiting kbucciero@intrexon.com