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Scientist/Senior Scientist, Autoimmunity

Precigen, Inc., Germantown, Maryland

Position Description:

Precigen, Inc., a wholly owned subsidiary of intrexon, is seeking a highly motivated and creative research Scientist/Senior Scientist, Autoimmunity (level determined by candidate experience) to join our team in Germantown, MD. This exciting opportunity will focus on autoimmune diseases and involves extensive hands-on experimental immunology. The successful candidate will have a strong background in immunology, characterization of T cells and autoimmune diseases. The successful candidate will have an in-depth understanding of T cell biology and significant experience with characterizing pathogenic or regulatory T cell phenotype and functionality.

Responsibilities:

  • Set up the evaluation strategy using in vitro studies with human or mouse T cells and in vivo murine models to test novel adoptive T cell therapies.
  • Perform correlative studies to evaluate the transfer, persistence and function of antigen-specific T cells in human clinical trials of adoptive T cell immunotherapy.
  • Utilize appropriate technology, i.e. Outlook, PowerPoint, and other programs to create and distribute reports and key information.
  • Coordinate parallel tasks across multiple projects, demonstrating prioritization to manage timelines and deliverables.
  • Interpret and effectively execute upon a variety of instructions provided in written, oral, diagram or schedule formats.

Education and Experience:

  • Ph.D. in Immunology, Cellular Biology or Molecular Biology.
  • Three (3) or more year’s post-doctoral experience in academia or industry.
  • Proficient in primary immune cell isolation from tissues and in primary tissue culture techniques; hands-on experience with mouse disease models (autoimmune and/or GVHD) is preferred.
  • Demonstrated experience in the following techniques or tools:
    1. Cellular Immunology: Functional cell based assays (proliferation, T cell activation, Treg suppression), multi-color flow cytometry, cytokine analysis (intracellular, ELISA, Luminex), CD4 T cell subset differentiation and analysis
    2. Molecular biology: electroporation and viral transduction of immune cells, qRT-PCR, Western blot
    3. Software: FlowJo, FACSDiva, statistical analysis (e.g. GraphPad Prism), Microsoft Office

Key Competencies:

  • Ability to understand and execute on the company’s mission and values.
  • Foster innovation through creative solutions.
  • Enjoy working as a member of a dynamic multidisciplinary team in an entrepreneurial environment.
  • Basic understanding of statistics, data analysis, and assessment of reproducibility and reliability of experimental data.
  • Ability to organize, interpret and communicate complex data sets and project updates in a clear and concise manner to key stakeholders.
  • Possess positive interpersonal skills including conflict resolution, with the ability to interact with individuals from a variety of levels and function.
  • Maintain a high degree of ethical standard and trustworthiness.
  • Capable of fostering change in an organization.
  • Energized by accomplishments and excellence in the workplace.

To Apply:

Please contact Kristy Bucciero, Director, Recruiting kbucciero@dna.com or Caroline Diamond, Senior Recruiter cdiamond@dna.com