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Staff Scientist - Biological Sciences and Genetics

National Human Genome Research Institute, Bethesda, Maryland

Position Description:

As a Staff Scientist in the Section of Molecular Neurogenetics he/she will be responsible for designing and performing cell biology research and related biochemical assays in the laboratory. The laboratory focuses on understanding disease pathogenesis and drug development for lysosomal storage disorders. Research will specifically encompass studies on the rare disorder Gaucher disease and its relationship to Parkinson disease.

Qualifications:

Experience with induced pluripotent stem cell (iPSC) technology, cell imaging, cell sorting, and biochemical characterization of animal models of disease is required. Familiarity with standard scientific protocols and techniques such as confocal microscopy, Western blotting, ELISA, PCR, high-throughput imaging, FACS sorting, statistical programs and RNAseq are highly desirable. The Staff Scientist will work to generate patient-derived iPSC and will characterize macrophages, neurons and glial cells made from new or available iPSC lines. These cell models will be used to validate new small molecule drugs identified as potential therapeutic agents for both Gaucher and Parkinson disease. The ability to design and carry out experiments independently yet work collaboratively within the group is mandatory.  Some teaching/oversight of student trainees is expected. These studies will impact the treatment of Gaucher disease and potentially Parkinson disease.

To Apply:

Please submit an application package including a CV and three references to Dr. Ellen Sidransky, sidranse@mail.nih.gov

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