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Staff Scientist - p53 Regulation

National Cancer Institute, Bethesda, Maryland

Position Description:

Our group studies the tumor suppressor protein p53, its roles in the cell and regulation by post-translational modification. Cellular, molecular biological, metabolic, molecular pharmacological and molecular modeling approaches are used. Recently we demonstrated that a small molecule targeting mutant p53 can alter the onco-metabolic profiles of cancer cells based on their different p53 mutational status, reducing cell proliferation and tumor growth.


Applicants must have a Ph.D. or M.D. at least six years of postdoctoral experience.  Candidates should have research experience in cancer cell biology, metabolomics techniques and an interest in oncogene driven cell signaling, specifically use of the Seahorse Bioanalyzer, Carbon tracing, multi-color immunofluorescence and flow cytometry are required. Prior experience in the field of p53 and post-translational modification would be desirable.

Salary is commensurate with research experience and accomplishments.  A full Civil Service package of benefits (including retirement, health, life and long-term care insurance, Thrift Savings Plan participation, etc.) is available.

To Apply:

This position is available immediately. Applicants should submit their curriculum vitae, names and email addresses of three references electronically to: Ettore Appella Ph.D., Senior Investigator, Chemical Immunology Section, Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, NIH, 37/2140, 37 Convent Drive, MSC 4256, Bethesda, MD 20892-4256; E-mail:


This post will be available until May 18, 2021 or until filled.

This position is subject to a background investigation.

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