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Postdoctoral and Senior Scientist Computational Biologist Positions

Weill Cornell College of Medicine, New York, New York

Position Description:

The Cancer and Glioma Stem Cell Biology Laboratory, part of the Weill Cornell Brain Tumor Center and Meyer
Cancer Center, is a highly interactive, translational research laboratory dedicated to the discovery of new basic
cancer biology and the translational of those discoveries into novel experimental therapeutics destined for the
clinic. The laboratory (a 2017 recipient of the NIH Directors Pioneer Award) is a highly translational
program/laboratory benefitting from exceptional resources, scientific freedom and extraordinary local
environment of world-renowned cancer biologists and neuroscientists. Our largest and most rapidly growing
area of interest focuses on single cell genomic and epigenomic gene regulatory networks and the resultant
developmental biology of the human brain and malignant glioma stem cells as influenced by the central nervous
system’s host microenvironment using a number of novel patient-derived ex vivo tumor models including studies
in embryonic and induced pluripotent stem cell-derived cerebral organoids. Our high throughput drug screening
core then allows the genetic and drug screening of promising network targets for dissecting out new biology and
developing promising new therapeutics.
A few of our publications that represent the kind of research we do include: Cancer Cell 39:1056, 2021; Cancer
Discovery 10:964-979, 2020; Cancer Discovery 9:1650-52, 2019; Cell Reports 26:3201-11, 2019; Cancer Cell.
9: 287-300, 2006; Cancer Research. 66(19): 9428-36, 2006; Cancer Cell. 9(5):391-403, 2006; Cancer Res.
6(1):21-30, 2008; Cancer Cell 13(1):69-80, 2008; Cell Stem Cell. 4(5): 440-52, 2009.; Cancer Research, 2009;
69(4): 1596-1603, 2009; Cancer Cell.15(4): 247-9, 2009; Cell Stem Cell 4(6): 466-7, 2009; Bioinformatics.
26:1792-3, 2010; Cancer Cell. 18:543-5, 2010; Nature Reviews Neurol 7:439-50, 2011; PLoS One 6:e14681,
2011, Cancer Cell 20:695-7, 2011; J. Natl. Cancer Instit. 103:1162-78, 2011; Cancer Cell 21; 710, 2012; PLOS
One 7:e51407, 2012, Cell Reports 6:313, 2014; PLoS One. 2014 Nov 3;9(11):e111783. doi: 10.1371; Cancer
Inform. 2014 Oct 15;13(Suppl 3):33-44. doi: 10.4137; Pharmacogenomics J. 2014 Dec 2. doi:
10.1038/tpj.2014.61.
The laboratory allows outstanding exposure to and potential involvement in all aspects of translational science
while exploring basic mechanistic studies of tumorigenesis using a combination of molecular and computational
biology approaches.
The position is a purely academic research one with the major responsibilities being to provide computational
expertise in the analyses of large genetic and epigenetic “-omics” data, most importantly single cell RNA-seq,
ATAC-seq and DNA sequence analyses. It is expected that the successful candidate will, in collaboration with
colleagues in the laboratory and the laboratory principle investigator, Dr. Fine, write scholarly manuscripts and
publish biomedical research papers in high impact peer reviewed journals.

To Apply:

Please email a letter of interest and curriculum vitae to Howard A. Fine, M.D. at: haf9016@med.cornell.edu.