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Biophysics of Transcription Factor Dynamics

University of Maryland, College Park, College Park, Maryland

Position Description:

Applications are invited for a Postdoctoral Research Associate in Single Molecule Imaging of Chromatin and Transcription Factor Dynamics at the Upadhyaya lab (arpitalab.github.io) at the University of Maryland, College Park.

In this project, the Postdoctoral Research Associate will investigate chromatin and transcription factor dynamics using single-molecule imaging, biophysical, and molecular biology approaches. The project aims to uncover how factors in the cellular microenvironment regulate chromatin accessibility and transcription factor mobility, organization and binding in cancer and immune cells. We work in close collaboration with the Hager laboratory at the NIH.

The successful candidate will have the freedom to design their project within the broad outlines of the lab’s interest areas and will be responsible for the day-to-day running of the project. The Upadhyaya lab is an open and inclusive environment and is dedicated to the career development of scientists, whether they wish to remain in academia or not.

Recent publications pertinent to this research project are:

Garcia et al. Mol. Cell 81:1484 (2021) PMID:33561389
Garcia et al. Nucleic Acids Research 49:6605 (2021) PMID:33592625
Wagh et al. Trends in Cell Bio 31:457 (2021) PMID:33712293
Rey et al. Mol. Biol. Cell 32:1641 (2021) PMID:33826369
Wagh et al. biorxiv (2022) https://doi.org/10.1101/2022.07.25.501476
Wheatley et al. Mol. Biol. Cell 33:ar88 (2022) PMID:35830602

Qualifications:

Applicants should possess (or be close to obtaining) a PhD in Physics, Biophysics, Biochemistry, Cell/Molecular Biology, Cellular Immunology or a related field. Familiarity with biochemical and biophysical approaches to study DNA-protein interactions and/or imaging to study cell and protein dynamics would be desirable. Experience with programming and image data analysis in MATLAB or Python is a plus.

To Apply:

Interested individuals should email a cover letter, a description of past research and future goals and their CV with three references to Arpita Upadhyaya at arpitau@umd.edu.