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Immunoengineering and Translational immunology

University of Pennsylvania and Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania

Position Description:

The MA LAB for immune engineering and translational immunology at the University of Pennsylvania and Children’s Hospital of Philadelphia (https://www.malabimmuneng.com/) is seeking motivated post-doctoral fellows to join our innovative laboratory to carry out cutting-edge research on immune system crosstalk and engineer innovative biomaterials, protein and cell-based immunotherapies.

We are a highly interdisciplinary team working at the interface of immunology and engineering. We leverage Chemical and biomaterials engineering to dissect and manipulate immune cell-cell and cell-tissue crosstalk to enhance cellular therapy and promote vaccine development, Genetic engineering and synthetic immunology to create intelligent cells that integrate environmental cues for decision making, Protein engineering to develop safe and potent immune-modulatory proteins and nanostructures with desired trafficking profile, release kinetics, enhanced or novel functions.

We have two postdoc fellow positions available with the following research focus:

  • Tailored immune modulation with chemistry/biomaterials to improve transplantation tolerance (and/or treatment of autoimmune diseases, e.g., T1D).
  • Engineering the next generation immunotherapy to target antigenically heterogeneous tumors.

Successful candidates will benefit from the thriving and collegial UPenn/CHOP research community, tailored career development guidance, state-of-the-art research facilities and excellent benefits package.

Qualifications:

Candidates should have a PhD and/or MD (or equivalent) degree in biomedical sciences, immunology, bioengineering, or chemistry. Ideal candidates will be highly independent, self-motivated, possess strong problem solving and critical thinking skills and have the ability to work in a team, exercise discretion and communicate effectively. Given the highly interdisciplinary nature of our projects, candidates are expected to be expert and technically proficient in at least two of the following topics: multi-color flow cytometry, florescent/confocal microscopy, HPLC, FPLC, immune cell profiling, biomaterials/nanoparticles, vaccine designs and synthesis (mRNA or nanoparticles), chemical synthesis/modifications/characterizations and purifications, mouse disease models, genetic circuit designs, CRISPR (Screen), deep-sequencing and data analysis, recombinant protein production/characterization and purification, vaccine designs and synthesis (mRNA or nanoparticles), viral vectors.

To Apply:

Applicants should send their inquiries to Dr. Ma (Leyuan.Ma@pennmedicine.upenn.edu) along with a CV, contacts for three references and a brief summary of research experience and interests. Happy to answer questions, feel free to email me.