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DNA Damage and Replication Stress

University of California, Davis, California

Position Description:
A postdoctoral fellow position is available in the Barlow laboratory in the Department of
Microbiology and Molecular Genetics. The focus of the Barlow laboratory is to elucidate the
molecular and genetic factors governing how DNA damage arises in response to replicative
stress using the mouse immune system as a model. The primary research aim of the laboratory
is to investigate how replication stress induces DNA damage in highly proliferative cell types
such as B and T lymphocytes, and to understand the mechanisms maintaining genome integrity
during DNA replication. The laboratory uses a combination of genetics, molecular biology, and
next-generation sequencing to investigate where and how DNA damage arises, define
mechanisms controlling cancer initiation and evolution, and identify novel molecular
determinants underlying cancer predisposition (http://microbiology.ucdavis.edu/barlow/).

Responsibilities:
The successful candidate is a highly motivated individual with a strong background in molecular
and cell biology or computational biology that will manage an independent research project. The
candidate will develop new assays, collaborate on multidisciplinary research projects, train junior
lab members, present data at scientific meetings, and help write manuscripts.

Qualifications:
Applicants must have a PhD in a relevant discipline. Training in cell biology, molecular biology
and genetics, as well as excellent oral and written English skills are required. Candidates with
experience in immunology, next-generation sequencing technologies, bioinformatics or
computational biology will receive special consideration.

To Apply:
Send a 1-2 page cover letter discussing the above selection criteria and reasons for joining the
lab, CV, and contact information for 3 or more references in a single PDF document to Dr.
Jacqueline Barlow at jhbarlow@ucdavis.edu. The position will remain open until filled.