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Epigenetic Modulators

The George Washington University, Washington, District of Columbia

Position Description:
Research and discovery is at the core of the mission of GW School of Medicine and Health Sciences. By advancing translation of research and increasing interdisciplinary collaboration in key areas of strength, SMHS researchers are identifying novel approaches to address the world's most devastating health issues.
Dr. Wu's lab in the Department of Medicine focuses on two epigenetic modulators and members of the AT-rich interaction domain family, ARID4A and ARID4B. Epigenetics plays an important role in human health and disease. Disruption of epigenetic modifications leads to dysregulation of gene function without altering the DNA sequence per se. A major challenge in understanding the importance of epigenetics in human health and diseases is to identify the specific epigenetic factors and the signaling involved.
Currently, we are investigating the role of ARID4A and ARID4B in development and cancer disease using state-of-the-art conditional knockout mouse models and genomic and proteomic approach. We also study the role of ARID4B in cancer stem cells that have been suggested as the major cause for therapy resistance and the driving force behind cancer metastasis and relapse. To investigate whether and how ARID4B drive cancer development, we evalute the underlying molecular mechanisms by which ARID4B promotes therapy resistance and aggressive cancer.

Dr. Wu's lab in the Department of Medicine has an opening for a Postdoctoral Scientist.
Duties include:

  • culture and transfection of mammial cells
  • collection of samples for reporter gene assays
  • western blooting to analyze protein expression
  • cancer cell migration and invasion assays -human cancer xenogrant experiments using SCID/NOD mice.
  • other duties as assigned. The omission of specific duties does not preclude the supervisor from assigning duties that are logically related to the position.

This post-doc scientist is also required to work with genetically modified mice and in a BSL2 laboratory setting.

To Apply:
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The university is an Equal Employment Opportunity/Affirmative Action employer that does not unlawfully discriminate in any of its programs or activities on the basis of race, color, religion, sex, national origin, age, disability, veteran status, sexual orientation, gender identity or expression, or on any other basis prohibited by applicable law.