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Nanotechnology Characterization Postdoctoral Fellow

Leidos Biomedical Research, Inc. , Frederick, Maryland

Position Desription:
The Cancer Research Technology Program (CRTP) develops and implements emerging technology, cancer biology expertise and research capabilities to accomplish NCI research objectives. The CRTP is an outward-facing, multi-disciplinary hub purposed to enable the external cancer research community. A major focus of the CRTP is the NCI RAS Initiative with the goal to discover new therapeutic interventions against RAS-driven cancers. In addition, the CRTP hosts the Nanotechnology Characterization Laboratory (NCL) which performs and standardizes preclinical efficacy and toxicity testing of nanoparticles intended for cancer therapeutics and diagnostics, and the Antibody Characterization Lab (ACL) which characterizes monoclonal antibodies or other renewable affinity binding reagents for use in cancer related research. CRTP scientists also work collaboratively with intramural NCI investigators to provide research technologies and expertise.

Key Roles/Responsibilities:

The postdoctoral fellow will perform basic research to investigate the mechanism(s) of nanoparticle toxicity to the immune cells. Isolate various immune cell subtypes for the whole blood derived from healthy donor volunteers. Perform cell-based assays and biochemical assays, as well as apply molecular biology techniques to unravel complex processes leading to the change in immune-cell function.

Expected Competencies:

  • Primary cell culture and co-culture
  • Western blotting
  • Flow Cytometry
  • Basic nanoparticle characterization (hydrodynamic size, zeta potential)

Basic Qualifications: To be considered for this position, you must minimally meet the knowledge, skills, and abilities listed below:

  • Possession of a doctorate degree from an accredited college or university according to the Council for Higher Education Accreditation. (Additional qualifying experience may be substituted for the required education). Foreign degrees must be evaluated for U.S. equivalency
  • No experience required beyond the doctorate degree
  • Must be able to obtain and maintain a security clearance

Preferred Qualifications:
Candidates with these desired skills will be given preferential consideration: 

  • (3) years of hands-on research experience in biomedical field
  • Experience with handling nanoparticles
  • Experience with isolation and analysis of various immune cell populations by flow cytometry

To Apply:
Please visit

This position is subject to a background investigation.