Skip to Content

Cardiovascular Redox Signaling

Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland

Position Description:
The Kohr Laboratory of Cardiovascular Redox Signaling has an immediate opening for apostdoctoral fellow position. This is an excellent opportunity to join an exciting, NIH‐fundedresearch team focused on demystifying sex‐specific, redox‐dependent differences in the heart'sresponse to ischemic injury with the ultimate goal of identifying novel, cardioprotective signaling pathways.

The role of protein S‐nitrosation in the female heart, which is naturally protected from
ischemic injury, is a major focus of current studies. We have developed a number of cutting‐edge
mass spectrometry‐based proteomic methodologies to map sites of S‐nitrosation and other
redox‐based modifications, and we use these in tandem with cellular, molecular, and biochemical
methods to assess the effects of S‐nitrosation on the function, stability, and localization of
specific protein targets. We also utilize a number of physiological approaches to evaluate
myocardial function, including the Langendorff‐perfused heart preparation, in vivo pressurevolume
loop analysis, and echocardiography. Our lab primarily utilizes cell and mouse‐based
models for experimentation. By defining female‐specific and other protective signaling pathways
in the heart, we are working to identify key therapeutic targets for the treatment of ischemic
heart disease in both men and women.

We are seeking a creative scientist to pursue independent and collaborative research within the
Bloomberg School of Public Health and the School of Medicine at Johns Hopkins University. State
of the art facilities and excellent core laboratories are available for research projects.The applicant should possess a PhD, MD, or equivalent. Preferred qualifications include experiencein heart physiology, proteomics and/or redox biology.

To Apply:
Interested applicants should send a cover letter and a curriculum vitae including publications in PDF format to: