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Structural Biology of the Multi-Protein Complexes in Transcription Regulation

Indiana School of Medicine, Indianopolos, Indiana

Position Description:

A post-doctoral position is available in the laboratory of Dr. Yuichiro Takagi in Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN (https://medicine.iu.edu/research/faculty-labs/takagi/). Takagi laboratory is interested in understanding the mechanisms of assembly, structure and function of large multi-protein complexes -“molecular machines” - involved in eukaryotic gene regulation, utilizing both cryo-EM and X-ray crystallography. We are particularly interested in the Mediator complex in both yeast and humans.  

We believe that development and implementation of novel technologies is the key to unlocking the mysteries of how highly complex molecular machines function. Therefore, our overall research objective is two-fold: (i) development of novel technologies for studying multi-protein complexes, and (ii) application of these technologies to elucidate the structure and function of the Mediator complex.  In addition, we have developed a novel technology for producing pure preparations of difficult-to-express proteins and protein complexes, which has enabled several exciting ongoing projects with outstanding collaborators, including work on: plant RNA polymerases, DNA helicases, DNA repair complexes, RNA editing complex, and insulator complex. 

Qualifications:

Highly motivated candidates should have a PhD in Structural biology (X-ray crystallography, cryo-EM), and an established publication record.

To Apply:

Interested candidates should apply electronically with a CV, a statement of research interest and career goals, and the names and contact information for three references to Yuichiro Takagi (ytakagi@iu.edu).  Applications will be screened until a suitable candidate is found. 

Indiana University is an equal opportunity/affirmative action employer.