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Postdoctoral Research Associateship: Nanomaterials/Neuroscience/Biophysics

US Naval Research Laboratory, Washington, District of Columbia

Position Description:

A postdoctoral research position is available immediately in the Center for Bio/Molecular Science and Engineering at the US Naval Research Laboratory, Washington DC (http://www.nrl.navy.mil/).The project, at the intersection of nanoscience and neuroscience, is aimed at the development of actuatable nanomaterial-based bioconjugates for the control of cellular membrane potential.

Our laboratory utilizes various nanomaterials (quantum dots, gold nanoparticles), molecular biology, protein and peptide engineering, FRET and cell biology to understand how to implement functional nanobioconjugates at the biotic/abiotic interface for the purposes of cellular labeling, imaging and sensing. This position presents an opportunity to work with a highly interdisciplinary group to create new types of nanomaterial-based sensors. This position is outside the NIH.

Qualifications:

The successful candidate will possess a multidisciplinary skill set including proficiency in the following:  cell culture (neuronal cell culture experience is desired but not required), quantitative cellular imaging, fluorescence and/or confocal microscopy and biophysics. A strong background and documented experience in molecular and cellular biology is essential. 
 
The Naval Research Laboratory is the Department of Defense’s corporate laboratory for the Navy and Marine Corps. The Center for Bio/Molecular Science and Engineering works at the interface of materials, chemistry, biology, biophysics and materials science to solve critical problems of importance to the Navy and DoD.
 
Availability: Immediately (no deadline date)
Salary: ~$77k/year with health benefits, conference travel allotment and relocation reimbursement.
Applicants must be either a US citizen or permanent resident/green card holder.
Fellowship is administered by either the National Research Council (NRC, http://sites.nationalacademies.org/pga/rap) or American Society for Engineering Education (ASEE, http://nrl.asee.org/) and the PhD must have been awarded within 5 yrs (NRC) or 7 yrs (ASEE) of the time of application.
 
Selected group publications:
Efros AL, Delehanty JB, Huston AL, Medintz IL, Barbic M, Harris TD. Evaluating the potential of using quantum dots for monitoring electrical
signals in neurons. Nat Nanotechnol. 13:278-288. (2018)

Sangtani A, Petryayeva E, Wu M, Susumu K, Oh E, Huston AL, Lasarte-Aragones G, Medintz IL, Algar WR, Delehanty JB. Intracellularly Actuated Quantum Dot-Peptide-Doxorubicin Nanobioconjugates for Controlled Drug Delivery via the Endocytic Pathway. Bioconjug Chem. 29:136-148 (2018)

Sangtani A, Nag OK, Field LD, Breger JC, Delehanty JB. Multifunctional nanoparticle composites: progress in the use of soft and hard nanoparticles for drug delivery and imaging. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2017 doi: 10.1002/wnan.1466. (2017)

Nag OK, Stewart MH, Deschamps JR, et al. Quantum Dot-Peptide-Fullerene Bioconjugates for Visualization of in Vitro and in Vivo Cellular
Membrane Potential. ACS Nano. 11:5598-5613 (2017)

Bradburne, C. E.; Delehanty, J. B.; Boeneman Gemmill, K.; Mei, B. C.; Mattoussi, H.; Susumu, K.; Blanco-Canosa, J. B.; Dawson, P. E.; Medintz, I. L. Bioconjugate Chemistry 24, 1570 (2013).

Delehanty, J. B.; Blanco-Canosa, J. B.; Bradburne, C. E.; Susumu, K.; Stewart, M. H.; Prasuhn, D. E.; Dawson, P. E.; Medintz, I. L. Chemical
Communications 49, 7878 (2013).

Boeneman, Gemmill, K.; et al., Selecting Improved Peptidyl Motifs for Cytosolic Delivery of Disparate Protein and Nanoparticle Materials. ACS Nano 7, 3778  (2013).

Oh, E., et al., PEGylated Luminescent Gold Nanoclusters: Synthesis, Characterization, Bioconjugation and Application to One- and Two Photon Cellular Imaging. Particle and Particle Systems Characterization 30, 453 (2013). 

Algar, W. R., et al.,Proteolytic Activity at Quantum Dot-Conjugates: Kinetic Analysis Reveals Enhanced Enzyme Activity and Localized          Interfacial “Hopping”. Nano Letters 12, 3793 (2012). 

Walters, R., et al.,Nanoparticle Targeting to Neurons in a Rat Hippocampal Slice Culture Model. ASN NEURO 4(6) art:e00099 (2012).  

Oh, E., et al.,Cellular uptake and fate of PEGylated gold nanoparticles is dependent on both cell penetration peptides and particle size. ACS Nano 5, 6434 (2011).

To Apply:

Interested and qualified candidates should submit a CV and three references to:
Dr James B. Delehanty
Research Biologist IV
US Naval Research Laboratory
Email: James.Delehanty@nrl.navy.mil