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Vaccine Development

University of Virginia, Charlottesville, Virginia

Position Description:

The postdoctoral fellow will work on developing new technologies aimed at turning the gastrointestinal (GI) immune system of a mouse into a technology called Intestinal Selection of Immunogenic Antigens (ISIA) that can distinguish highly immunogenic antigens from less immunogenic antigens and will apply the new technology to vaccinology. The technology employs a combination of synthetic biology, new insights into the microbiome, the notion of DNA barcoding, and Gram-negative autotransporters to interrogate, without any advance assumptions or biases, the entire, intact GI immune system of a mouse. The work will also involve developing new candidate recombinant vaccines for viral diseases, such as HIV, using these new technologies, in combination with those of classical molecular biology and virology, synthetic biology, and recombinant expression systems.

The University of Virginia is annually ranked as one of the premier public institutions in the United States and is located in Charlottesville, a picturesque small, but cosmopolitan city perennially ranked as one of the best places to live in the U.S., about a 2.25 hour drive from Washington, DC. In addition to substantial current collaborations with investigators at the University and other institutions, extensive opportunities for collaboration exist across the University, including investigators from basic science departments in the School of Arts and Sciences, the School of Engineering and Applied Science, and basic science and clinical departments in the School of Medicine.

To Apply:

Please contact:

Steven L. Zeichner, MD, PhD
McLemore Birdsong Professor
Departments of Pediatrics & Microbiology, Immunology, and Cancer Biology
Director, Pendleton Pediatric Infectious Disease Laboratory
The University of Virginia