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Inflammation And Therapeutic Antibodies In Animal Models Of Brain Ischemia And Hemorrhagic Shock

University of Maryland School of Medicine, Baltimore, Maryland

Position Description:

The Shock, Trauma and Anesthesiology Research (STAR) Center is currently in search of two (2) Post-Doctoral candidates. The selected candidate(s) will be responsible for: (i) develop and characterize a transgenic mouse model of brain ischemia; and (ii) develop and characterize neuroprotective antibodies in a mouse model of focal brain ischemia (stroke).

One project is to study the role of inflammatory and immune response in tissue ischemia-reperfusion injury using animal models of brain ischemia and hemorrhagic shock. Another project is to study Alzheimer’s disease biomarkers, as well as to develop mouse monoclonal antibodies and molecular ELISA immunological assays using the Simoa HD-1 Analyzer. The third project will use mouse brain ischemia models to investigate pathophysiological mechanisms of neuronal cell death and the development of neuroprotective treatments. The programs are highly interdisciplinary, utilizing animal surgery, monoclonal antibody production, development of transgenic animal model, molecular and cellular biology, biochemistry, pharmacology, and quantitative histological analysis.

Qualifications:

PhD and/or MD degree in biomedical fields is required.  Candidates must be highly motivated and able to work independently with the ability to work in a dynamic team environment.  Candidates should have exceptional organizational skills and strong oral and written communication skills. Candidates with experience in inflammation research, animal stroke and trauma models, monoclonal antibody production, and transgenic mouse model are preferred. 

To Apply:

Interested candidates should send their CV and/or references to Professor, Bingren Hu, MD, PhD at bhu@som.umaryland.edu of Shock, Trauma and Anesthesiology Research Center, University of Maryland School of Medicine.