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Antibody-Dependent Enhancement for Therapeutics Targeting Neurotropic Viruses

Center for Drugs Evaluations and Research, Food and Drug Administration , Silver Spring, Maryland

Position Description:

A post-doctoral Research Biologist (contractor) position is available immediately in the Laboratory of Innate Immunity headed by Daniela Verthelyi in the Office of Biotechnology Products (OBP) at the Center for Drugs Evaluations and Research, US-FDA. The lab develops animal models to understand host-pathogen interactions between neurotropic viruses and their host and explores the impact of innate immune response modulators on disease progression and neurological sequelae. Working with murine and primate models we established that Toll like receptor agonists can enhance immune function in HIV-infected and other immunocompromised patient populations, and determined that direct modulation of the immune response can modulate the severity of different viral encephalitis. The current project involves the development of in vitro and in vivo systems to assess the risk of antibody-dependent enhancement for therapeutics targeting neurotropic viruses.

This position will be appointed for one year via a fellowship from ORISE (see http://orise.orau.gov/fda/), with the potential for renewal on an annual basis (contingent on excellent performance). ORISE fellowships are available for U.S. citizens, non-citizens with permanent resident status, or non-citizens that are eligible for a J-1 visa, and must have resided in the US for at least 3 of the last 5 years. Salary is commensurate with experience and includes an allowance for mandatory health insurance.

Qualifications:

The optimal candidate will have a PhD degree in immunology or neuroimmunology and experience in virology and/or the use of animal models (rodent and NHP). Independence, initiative, and excellent verbal and writing communication skills are required.

To Apply:

Qualified candidates should send in electronic format: a detailed curriculum vitae, including descriptions of laboratory experience, responsibilities, and/or pertinent recent coursework; a short cover letter outlining research interests, research experience, and future goals; and names of at least 3 scientists or faculty as references (with contact information, including e-mail addresses and phone numbers) to daniela.verthelyi@fda.hhs.gov. Please include the words “Post-doctoral application” on the subject line. Applications will be reviewed until the position is filled.