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T cell Immunoregulation and Tissue Injury/repair

National Institutes of Health and Purdue University, Bethesda, Maryland

Position Description:

A postdoctoral position is available (open until filled) for an enthusiastic scientist to work in the area of T cell immunology. The post is part of a multi-disciplinary collaboration between wet and dry labs at Purdue University (Kazemian lab) and the NIH (Afzali lab). These labs focus on the regulatory circuitries underlying immune cell fate decisions, their relationship to tissue inflammation/repair and cancer development. Examples of outputs from this collaboration include the following:

  1. Kolev M, West E, Kunz N, Chauss D, Moseman E, Rahman J, Freiwald T, Balmer M, Loetscher J, Dimeloe S, Rosser E, Wedderburn L, Mayer-Barber K, Bohrer A, Lavender P, Cope A, Wang L, Kaplan M, Moutsopoulos N, McGavern D, Holland S, Hess C,  Kazemian M*,  Afzali B*, Kemper C*, “Diapedesis-induced integrin signaling via LFA-1 facilitates tissue immunity by inducing intrinsic complement C3 expression in immune cells”. Immunity 2020; 52(3): 513-527. *Joint last authorship. (Immunity)
  2. Chakravorty S, Yan B, Wang C, Majumder J, Wang L, Olson M, Canaria A, Chauss D, Chopra G, Zhao B, Afzali B, M. Kazemian, Integrated pan-cancer map of EBV-associated neoplasms reveals functional host-virus interactions, Cancer Research, 1;79(23):6010-6023, 2019. (Cancer Research)
  3. Povoleri GAM, Nova-Lamperti E, Scottà C, Fanelli G, Chen Y-C, Becker P, Boardman D, Constantini B, Romano M, Pavlidis P, McGregor R, Pantazi E, Chauss D, Sun H-W, Shih H-Y, Cousins D, Cooper N, Powell N, Kemper C, Pirooznia M, Laurence A, Kordasti S, Kazemian M, Lombardi G*, Afzali B*. Retinoic acid-regulated CD161+ Tregs support wound repair in intestinal mucosa. *Joint last authorship. Nature Immunology 2018; 19: 1403-1414. (Nature Immunology)

The successful candidate will be based in the Immunoregulation Section of the Kidney Diseases Branch of NIDDK at NIH (Immunoregulation Section). They will leverage high throughout methodologies (RNA-seq, ChIP-seq, CUT&RUN, ATAC-seq, RNAi screening etc) to study basic and translational T cell immunoregulation. Candidates are expected to be independent and self-motivated with experience and/or knowledge of contemporary high-throughput sequencing techniques. Experience of immunological mouse models is highly desirable for this post.

Qualifications: 

  • PhD in molecular and cell biology, immunology or related fields;
  • Experience of mouse models of immunology
  • Experience in mammalian cell isolation, transfection techniques, cell culture, flow cytometry, in vitro gene manipulation, RNA isolation and handling, hands-on expertise in molecular biology and transcriptional regulation;
  • Being able to perform high-throughput sequencing library preparation is highly desirable;
  • Strong oral and written communication skills;
  • Excellent organizational and record keeping skills with high attention to detail
  • Ability to work independently as well as collaboratively with others;
  • Personal and professional integrity;
  • Flexibility in work scheduling

To Apply: 

Please submit your CV and cover letter outlining your interests and accomplishments, plus three letters from referees, to behdad.afzali@nih.gov. Please indicate in your cover letter why you are interested in joining our group. Applications will only be considered once all three references have been submitted.

 

This post will be available until June 19,2020.

Purdue University is an EOE / AA employer. The NIH is dedicated to building a diverse community in its training and employment programs. All individuals, including minorities, women, individuals with disabilities, and veterans are encouraged to apply.