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AstraZeneca, Gaithersburg, Maryland

Position Description:

We’re currently looking for talented scientists to join our innovative academic-style Postdoc. From our site in Gaithersburg, MD, you’ll be in a global pharmaceutical environment, contributing to live projects right from the start. You’ll take part in a comprehensive training program, including a focus on drug discovery and development, given access to our existing Postdoctoral research, and encouraged to pursue your own independent research in cutting edge laboratories. It’s a newly expanding program spanning a range of therapeutic areas across a wide range of disciplines.

What’s more, you’ll have the support of a leading academic advisor, who’ll provide you with the guidance and knowledge you need to develop your career. This is an exciting area that hasn’t been explored to its full potential, making this an opportunity to make a real difference to the future of medical science.

About the opportunity
Do you want the opportunity to work in collaboration with our Oncology Research team, and with a world leader in epigenetics at Johns Hopkins University? Then we're looking for you.

The Department of Oncology Research at AstraZeneca is seeking a highly motivated scientist for a postdoctoral fellowship to develop and lead a collaborative research project focused on elucidating how epigenetic mechanisms regulate T cell and CAR-T cell dysfunction in cancer.

This vital role will employ state-of-the-art technologies and automation tools, while also learning from a highly-skilled team of scientists in the field of biologics and drug development.

This is a hands-on, laboratory-based position, whereby the successful applicant will carry out extensive in vivo and in vitro studies and will be expected to present their research internally and at scientific conferences, ultimately publishing high-impact work in peer-reviewed journals. The Postdoc will design experiments, make detailed observations, analyze data, and interpret results independently.


  • Ph.D. in Immunology, Cancer Biology, Epigenetics, Molecular Biology, or related field
  • In depth in vivo experience with syngeneic murine tumor models or CAR-T models.
  • Prior history publishing in high-quality, peer-reviewed journals.
Desirable Qualifications:
  • 1-3 years of relevant post graduate research experience
  • Familiarity and experience with RNA-seq, ChIP-seq, and ATAC-seq (sample prep and data analysis).
  • Experience working with primary human T cells and human tumors.
  • Experience with in vitro cell-based functional assays (cell proliferation, apoptosis, cytolysis, etc.).
Skills and Capabilities required:
  • Desire to apply cutting-edge technologies to elucidate novel epigenetic mechanisms that regulate T cell dysfunction in cancer.
  • Demonstrated hands-on skills in immunological and biochemical methods including multi-color (10+ channels) flow cytometry (FACS), FACS-based cell sorting,
  • ELISA/multiplex assays, ELISpot, western blotting, immunoprecipitation, and CRISPR/Cas9 genome editing.
  • A deep knowledge of immunology and/or epigenetics.
  • Bioinformatics knowledge to analyze large-scale -omics datasets.
  • Proven ability to collaborate in a matrixed environment.
  • Ability to prepare detailed technical summaries, protocols, and quantitative analyses.
  • Excellent oral and written communication skills.
  • Experience with sourcing materials (e.g. human biological samples, reagents, NGS sequencing services, etc.) as needed.

To Apply:

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This post will be available until July 17, 2020 or until filled.

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements.

The NIH is dedicated to building a diverse community in its training and employment programs.