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Hematology

Oak Ridge Institute for Science and Education (ORISE) , Silver Spring, Maryland

Position Description:

*Applications will be reviewed on a rolling-basis.

A research opportunity is available in the Office of Blood Research and Review (OBRR), at the Center for Biologics Evaluation and Research (CBER), Food and Drug Administration (FDA) in Silver Spring, Maryland.

Overall area of research is an assessment of quality of human platelets stored or processed by conventional and novel methods to optimize their use as transfusion products. This particular project is aimed at developing an animal model to monitor contribution of platelets to in vivo hemostasis and to identify which platelet in vitro markers can be used to predict hemostatic efficacy. Transgenic mice, humanized with protein receptors for binding of human platelets to endothelial cells, will be used in intravital experiments to monitor interaction of human platelets with a developing localized clot and to correlate with reduction of bleeding. Cell to cell interactions can be visualized with 2 photon confocal microscopy in live animals with fluorescently labeled platelets, leucocytes and endothelial cells. Additional fluorescently labeled proteins and cells can be infused and detected by microscopy. Additional fluorescently labeled proteins and cells can be infused and detected by microscopy. Specific learning opportunities for the participant include experience in processing and storing human transfusion products such as red cells and platelets, maintaining a transgenic mouse breeding colony, operating a 2 photon confocal microscope, designing and carrying out intravital confocal microscopy experiments and preparing tissue slides for confocal microscopy.     

Anticipated Appointment Start Date: July 1, 2020

This program, administered by ORAU through its contract with the U.S. Department of Energy to manage the Oak Ridge Institute for Science and Education, was established through an interagency agreement between DOE and FDA. The initial appointment is for one year, but may be renewed upon recommendation of FDA contingent on the availability of funds. The participant will receive a monthly stipend commensurate with educational level and experience. Proof of health insurance is required for participation in this program. The appointment is full-time at FDA in the Silver Spring, Maryland, area. Participants do not become employees of FDA, DOE or the program administrator, and there are no employment-related benefits.

Qualifications:

The qualified candidate should have received a doctoral degree in one of the relevant fields, or be currently pursuing the degree and will reach completion by the appointment start date. Degree must have been received within five years of the appointment start date.

Preferred skills:
  • Experience in work with animals (rodents), animal surgery, confocal microscopy, and flow cytometry 
  • Clinical lab experience with cell counters and blood cell processing and storage

This opportunity is available to US citizens and Lawful Permanent Residents (LPR) only.

To Apply:

Apply at: https://www.zintellect.com/Opportunity/Details/FDA-CBER-2020-0044

Application Deadline: October 12, 2020 3:00PM EST

A complete application consists of:
  • An application
    Transcript(s) – For this opportunity, an unofficial transcript or copy of the student academic records printed by the applicant or by academic advisors from internal institution systems may be submitted. All transcripts must be in English or include an official English translation. Click here for detailed information about acceptable transcripts.
  • A current resume/CV, including academic history, employment history, relevant experiences, and publication list
    One educational or professional recommendation

All documents must be in English or include an official English translation.

If you have questions, send an email to ORISE.FDA.CBER@orau.org. Please include the reference code for this opportunity (FDA-CBER-2020-0044) in your email.

 

This post will be available until September 25, 2020 or until filled.

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