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Malaria Parasite Gene Regulation

Oak Ridge Institute for Science and Education (ORISE), Silver Spring, Maryland

Position Description:

*Applications will be reviewed on a rolling-basis.
Two research opportunities are currently available with the Office of Vaccines Research and Review (OVRR), at the Center for Biologics Evaluation and Research (CBER), Food and Drug Administration (FDA) located in Silver Spring, Maryland.

One selected fellow will perform experiments on the molecular characterization of the proteins involved in post-transcriptional regulatory mechanisms during various stages of parasite development. This is a pioneering project that seeks to define the global post-transcriptional regulatory processes involved in parasite transmission. The results of these studies will help establish the essential RNA-binding proteins that promote parasite development and lay the groundwork to identify novel targets for both chemotherapeutic or vaccine interventions.

One selected fellow will contribute to the bioinformatic design and implementation of computational pipelines for the analysis of bulk, targeted and and single cell RNAseq datasets. These datasets will be generated from the human malaria parasite at various stages of development, under different environmental conditions, and/or bound to proteins of interest.

Anticipated Appointment Start Date: June 2021

This program, administered by ORAU through its contract with the U.S. Department of Energy to manage the Oak Ridge Institute for Science and Education, was established through an interagency agreement between DOE and FDA. The initial appointment is for one year, but may be renewed upon recommendation of FDA contingent on the availability of funds. The participant will receive a monthly stipend commensurate with educational level and experience. Proof of health insurance is required for participation in this program. The appointment is full-time at FDA in the Silver Spring, Maryland, area. Participants do not become employees of FDA, DOE or the program administrator, and there are no employment-related benefits.

Qualifications:

The qualified candidate should be currently pursuing or have received a master's or doctoral degree in one of the relevant fields. Degree must have been received within five years of the appointment start date.
Preferred skills:
  • Tissue culturing
  • RNA-sequencing
  • Proteomics
  • Bioinformatics (Python, R)
  • Strong written and oral communication skills

To Apply:

A complete application consists of:
  • An application
  • Transcript(s) – For this opportunity, an unofficial transcript or copy of the student academic records printed by the applicant or by academic advisors from internal institution systems may be submitted. All transcripts must be in English or include an official English translation. Click here for detailed information about acceptable transcripts.
  • A current resume/CV, including academic history, employment history, relevant experiences, and publication list
  • One educational or professional recommendation

All documents must be in English or include an official English translation. The deadline for this application is June 3, 2021.

If you have questions, send an email to ORISE.FDA.CBER@orau.org. Please include the reference code for this opportunity (FDA-CBER-2021-0015) in your email.