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Translational Research in Malignant Glioma

Icahn School of Medicine at Mount Sinai, Department of Neurosurgery, New York, New York

Position Description:

POSTDOCTORAL POSITION is available in the Yong Laboratory in the Department of Neurosurgery at Mount Sinai, New York City, to identify and develop novel, precision strategies for the treatment of malignant gliomas. A current area of interest is the use of epigenetic agents to enhance responses of MGMT-unmethylated glioblastomas to temozolomide. The research fellow will use a large bank of spheroid primary cell lines, freshly derived from surgical specimens, to identify and validate biomarkers of chemosensitization for clinical use using cell culture experiments and mouse xenograft models. The research is a collaborative effort among faculty in the Departments of Neurosurgery, Oncological Sciences, Pathology, and Genetics and Genomic Sciences, with the opportunity to work with multiple PIs. The successful candidate will integrate detailed sequencing and molecular data from bulk tissue and cell lines with in vitro and in vivo experimental findings to perform hypothesis-driven translational neuro-oncology research. The fellow will be encouraged to initiate and develop independent lines of inquiry.
General Responsibilities/Duties
  • Design and conduct research experiments in the field of neuro-oncology.
  • Perform standard in vitro molecular biology, biochemistry, and imaging/microscopy techniques, including: RNA extraction, protein extraction, DNA extraction, Western blot, PCR and RT-qPCR, immunofluorescence, agarose gels, colorimetric assays, primer design, gene knockdown, etc.
  • Handle, inject, engraft, and dissect mice
  • Culture and maintain multiple cell lines from fresh surgical specimens
  • Collect, prepare and analyze research data using statistical methods, and integrate findings with the scientific literature
  • Keep a detailed notebook summarizing experiments, and maintain electronic records
  • Present and discuss data in research conferences
  • Participate in manuscript and grant writing
  • Participate in the training of other fellows, residents, students and volunteer workers as needed
  • Assist with ordering of supplies and general lab maintenance as needed
  • Attend relevant national and international research conferences for the presentation of scientific work


Minimum Qualifications
  • A doctoral degree (PhD), MD, MD/PhD, or equivalent in molecular biology, biochemistry, or a related field with a demonstrated track record of productive research
  • A strong background in molecular and cellular biology techniques
  • Experience in mouse models of cancer
  • An ability to generate new ideas and build upon existing ideas to generate unique concepts and solutions
  • Proven ability in scientific writing for academic journals and excellent spoken communication skills
  • Prior postdoctoral research experience
  • Experience in basic bioinformatics techniques for the analysis of next-generation sequencing data, including single cell RNA-seq data
  • Experience in grant writing
  • Experience in basic/translational glioblastoma research

To Apply:

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