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Regenerative Therapies for Inherited Blood Disorders

National Heart, Lung, and Blood Institute, Bethesda, MD and surrounding area

Position Description:

The Division of Intramural Research (DIR) of the National Heart, Lung, and Blood Institute (NHLBI) is seeking to recruit an outstanding post-doctoral fellow to participate in the research program of the Section for Regenerative Therapies for Inherited Blood Disorders of the Cellular and Molecular Therapeutics Branch (CMTB), led by Dr. Andre Larochelle.
(https://www.nhlbi.nih.gov/science/regenerative-therapies-inherited-blood-disorders)

This laboratory is investigating novel strategies and stem cell concepts to advance the translational field of regenerative medicine, with a focus on inherited disorders affecting blood-forming hematopoietic stem cells (HSCs), including:

  • In Vivo and Ex Vivo Gene Therapy: Genetic correction of adult HSCs using CRISPR/Cas technologies, viral/non-viral delivery approaches (e.g. lipid nanoparticles), and ex vivo expansion of genetically corrected HSCs;
  • Cell Therapy: Derivation of engraftable HSCs from genetically corrected induced pluripotent stem cells (iPSCs).

This position will primarily focus on the latter section (cell therapy) and requires prior experience in culture and differentiation of iPSCs.

Qualifications:

  • Ph.D. and/or M.D. (or anticipate receiving their degree in the near future).
  • Laboratory skills in iPSC culture, CRISPR genome editing, animal handling, and other general molecular/cellular biology.
  • Verbal and written proficiency in English, as demonstrated by peer-reviewed publications, and local, national or international presentations.
  • Demonstrated ability to work efficiently both independently and within a multi-disciplinary team.
  • Willingness to mentor trainees.
  • Appointees may be US citizens, resident aliens, or non-resident aliens with or eligible to obtain a valid employment authorized visa.

To Apply:

Applications should include:

  • Cover letter outlining the applicant's career and research goals and interests;
  • Curriculum vitae including applicant's education, research experience, publications, oral presentations, list of honors, awards, and other special recognition, and names/contact information for three references; at least one from a research mentor. Please submit this information as a single PDF to Eloise Huneidi (Eloise.huneidi@nih.gov).

The NIH is dedicated to building a community in its training and employment programs and encourages the application and nomination of qualified women, minorities, and individuals with disabilities.