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CNS Tumor Biology: Genomic/Epigenomic Landscape of Pituitary and CNS Tumors

National Institute of Neurological Diseases and Stroke, Bethesda, MD and surrounding area

Position Description:

The Neurosurgery Unit for Pituitary and Inheritable Diseases seeks applications from qualified and interested post-doctoral candidates to fill a position in tumor biology and physiology of mammalian pituitary gland and central nervous system (CNS) tumors. Using surgery derived human tissue samples, our group has made key insights into the pathogenesis of pituitary adenomas (PMID: 36001971, 28505327, 28986303) and other central nervous system (CNS) tumors (PMID: 28094316, 28094316) . Recently, our group identified the transcriptional landscape of the post-natal human pituitary gland and identified key pathogenic mechanisms underlying pituitary adenomas that cause Cushing’s disease. In the meantime, our group has actively accrued bulk RNAseq, single cell/single nucleus RNAseq, single cell multiome, bulk methylation and genomic sequencing datasets for pituitary (normal and adenoma), schwannomas and other CNS tumors associated with neurofibromatosis type 2 (NF2) and von Hippel Lindau disease (VHL).

Core responsibilities:

  • Working with dedicated bioinformaticians in currently in the lab, the candidate will analyze richly annotated, existing datasets to derive key insights into post-natal canonical cell class states (related to endocrine disorders), tumor cell evolution, intra-tumoral and inter-tumoral (within patient) heterogeneity, and genotype-phenotype associations in inheritable diseases (NF2 and VHL).
  • Selected candidates will then design projects to investigate and validate the findings mechanistically. The candidates will lead specific projects and manuscripts arising from these analyses. The candidates will work in a highly collaborative environment with other bio-informaticians, a staff scientist, other post-docs, students, and clinicians in the group.

Start date:

  • We are looking for qualified candidates to start during the second half of 2023, however, the start date may be flexible.

Stipends/benefits:

  • The salary will be commensurate with experience, based on the NIH Postdoctoral Intramural Research Training Award and Visiting Fellow scale; medical insurance coverage will be provided. The position is renewable for up to five years.

Qualifications:

Applicants must have a doctoral degree in molecular biology, tumor biology, endocrinology, or a related area. Candidates should have experience in in designing and implementing translational projects. Previous experience with human derived primary cell cultures is a plus.

To Apply:

Interested candidates may send a brief cover letter (research and career goals), current curriculum vitae, and the names/contact information for three references to prashant.chittiboina@nih.gov. Candidates will be able to meet with the current lab members, core personnel and the bioinformatics personnel.

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