Skip to Content

Neurodegeneration– GBA1 and Parkinson Disease

National Human Genome Research Institute, Bethesda, MD and surrounding area

Position Description:

Neurodegeneration– GBA1 and Parkinson disease
We are seeking a talented and enthusiastic postdoctoral fellow to join our team in the Molecular Neurogenetics Section (MNS) at the National Human Genome Research (NHGRI), NIH, located in Bethesda, Maryland.
The MNS, led by Ellen Sidransky, M.D., focuses on the causes of phenotypic diversity encountered in a single gene disorder, applying the insights gained to better understand complex disease. Gaucher disease, the prototype disorder studied, is the recessively inherited deficiency of the lysosomal enzyme glucocerebrosidase. This well-characterized disorder has broad clinical diversity, ranging from death in utero to asymptomatic octogenarians, with both non-neurologic and neuronopathic forms. Her group recognized an important relationship between Gaucher disease and Parkinson disease (PD), a common, multifactorial disease. Our current research aims to elucidate the relationship between glucocerebrosidase and PD, to identify factors contributing to clinical heterogeneity in single gene disorders, and to develop new therapies for patients. We employ a broad range of molecular and cell biology techniques (molecular cloning, gene editing, patient-derived iPSCs, protein biochemistry, fluorescence microscopy, etc) as well as mouse models of Gaucher disease and PD.
The incumbent will join a group of bench scientists and clinicians to investigate the relationship between Gaucher disease and PD using iPSC-derived disease models, biochemical and cellular assays, genomic sequencing, etc.

Qualifications:

While candidates with a wide range of expertise will be considered, applicants with a background in iPSCs, organoids, proteomics and/or Next Generation Sequencing are especially encouraged to apply.

To Apply:

Applicants should send a brief statement of research interests, their curriculum vitae and the names of three or more references to Dr. Ellen Sidransky (ellen.sidransky@nih.gov).

The NIH is dedicated to building a community in its training and employment programs and encourages the application and nomination of qualified women, minorities, and individuals with disabilities.