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Genetic, Epigenetic, and Environmental Epidemiology of Respiratory Disease Across the Life Course

National Institute of Environmental Health Sciences, Research Triangle Park, NC

Position Description:
A postdoctoral position is available, under the direction of Stephanie J. London, MD, DrPH at NIEHS/NIH (www.niehs.nih.gov/research/atniehs/labs/epi/pi/genetics) to participate in an ongoing research program investigating the role of environmental exposures, epigenetics, and genetics in asthma, allergy, and pulmonary function across the life course.

Current work includes studies of childhood and adult asthma and allergic disease, pulmonary function, and chronic obstructive pulmonary disease. We consider the role of early life and current exposure in these conditions as well as the role of genetics and epigenetics using genome wide approaches. Much of this work takes a consortium approach in consortia including Pregnancy and Childhood Epigenetics (PACE) and the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE). Work in the PACE Consortium examines the impact of in utero exposures on methylation patterns at birth as well as the impact of methylation at birth on childhood outcomes. Another project is a study of adult asthma among farmers and spouses nested within a large agricultural cohort: data collected on over 3,000 individuals include pulmonary function, airway inflammation, objective measures of allergy, exposures measured in dust (endotoxin, microbiome) and by questionnaire, and genome wide genotyping and methylation data (Illumina EPIC chip). We are examining farm exposures in relation to respiratory and allergic outcomes in this unique farming population. Applicants can work on more than one of these projects. Postdocs are encouraged to use these resources to develop new projects that can form the basis for transition to independence awards.

Qualifications:
Candidates must have a doctoral degree (PhD or equivalent) in epidemiology, biostatistics, genetics or a related field. Applicants must have extensive experience with epidemiologic or statistical data analysis. Experience with analysis of high dimensional genetic or epigenetic data is a plus but not required.

Postdoctoral fellows are encouraged to take advantage of the rich and varied training and career development opportunities offered at NIEHS as well as local universities.

To Apply:
Please email cover letter, curriculum vitae including list of publications in peer-reviewed journals, and the names/phone numbers/emails addresses of three people who could provide letters of reference to: Stephanie J. London, M.D., Dr.P.H. london2@niehs.nih.gov.

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