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Postdoctoral Fellowship to study Gene Regulation in Brain Neuroinflammation.

National Institute of Child Health and Human Development, Bethesda, MD and surrounding area

Position Description:
Study innate immune responses by microglia in mouse models of neuroinflammatory/neurodegenerative diseases (Alzheimer's disease, stress induced encephalopathy, RVCL). Analysis of single cell transcriptome and chromatin status. High resolution imaging of the brain. 

This group works on epigenetics of innate immunity in macrophages, dendritic cells and more recently microglia in the context of mutations that cause chronic inflammatory diseases. We investigate the role of transcription factor IRF8, chromatin binding protein BRD4, and the variant histone, H3.3.

The laboratory is part of Division of Developmental Biology of the National Institute of Child health and Human Development, NIH. The laboratory is located in the Bethesda main campus. It is furnished with the equipment and IT service necessary for the project and is adjacent to the animal facility. The P.I is an established scientist with broad knowledge and experience in cytokines and gene regulation. Beside P.I, the laboratory is composed of two senior scientists, several post-doctoral fellows and a post-bac fellow. There are active collaborations with other laboratories within and outside NIH, making the laboratory an dynamic and exciting place.

Qualifications:
This position requires prior experience in mouse genetics (such as genotyping), basic immunology (including flow cytometry), and molecular genetics (e,g., cloning, PCR). Deep sequencing, bioinformatics and high resolution microscopy are employed for the project. 

To Apply:
Please send a CV (with bibliography and references) and a brief narrative on past experience, research interest and future goals to Keiko Ozato at ozatok@nih.gov. The narrative should be concise (less than three paragraphs).

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