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Cytokine Immunology and Immunotherapy

National Cancer Institute, Bethesda, MD and surrounding area

Position Description:
The National Institutes of Health (NIH), Department of Health and Human Services (HHS), in Bethesda, Maryland, the world's largest medical research facility, seeks applications from exceptional candidates for the position of Postdoctoral Fellow in the Cytokine Immunology and Immunology Section (CIIS) under the supervision of Dr. Thomas A. Waldmann in the Lymphoid Malignancies Branch (LYMB), Center for Cancer Research (CCR), National Cancer Institute (NCI). This individual will utilize genomic technologies to discover essential signaling pathways in T-cell leukemia/lymphomas, define synergies between drugs with the assistance of a high-throughput matrix screen, and perform biochemical studies to define the therapeutic mechanisms underlying drug synergies. Most critically, the individual will evaluate therapeutic drug combinations directed toward novel molecular targets with the use of murine models of T-cell leukemia and Hodgkin's lymphoma. There will be a special focus on inhibitors of the JAK/STAT pathways to exploit discovery of disorders of the common gamma cytokine γc, JAK1, JAK3 and STAT5 pathway in T-cell malignancies including human T-cell lymphotropic virus-1 (HTLV-1) associated adult T-cell leukemia/lymphoma (ATLL). Agents showing promise in these murine models may move forward into clinical trials.

Experience Required:
Applicants should have completed an M.D. or Ph.D. and have a strong record of experience in immunology, oncology and particularly in the evaluation of therapeutic agents in murine models of malignancies. Salary is commensurate with research experience and accomplishments.
United States citizenship is not required.

To Apply:
Please submit curriculum vitae and three letters of reference via E-mail to: tawald@helix.nih.gov or mail to: Thomas A. Waldmann, M.D., Chief, Lymphoid Malignancies Branch, National Cancer Institute, Center for Cancer Research, National Institutes of Health, 10 Center Drive, Building 10, Room 4N115, Bethesda, Maryland 20892-1374.

The NIH is dedicated to building a diverse community in its training and employment programs. DHHS, NIH, and NCI are Equal Opportunity Employers