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Genomic and Mechanistic Studies of Transposable Elements and HIV-1

Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD and surrounding area

Position Description: 
A postdoctoral position is available to study the mechanisms and impact of Long Terminal Repeat-retrotransposons and retroviruses. The LTR-retrotransposon Tf1 in the fission yeast Schizosaccharomyces pombe is an excellent model for retrovirus replication. Saturated profiles of integration sites reveal the impact Tf1 has on the biology and evolution of S. pombe. Current projects include how integration promotes the formation of gene regulatory networks. Other work is to determine at a mechanistic level how host factors contribute to integration. Our studies of integration also include a large-scale dataset of HIV-1 integration that revealed the targeting mechanism is linked to mRNA splicing. Research is also conducted on other transposable elements to develop TnSeq technology capable of generating genome-wide profiles of gene function. Further details and a list of publications can be found at:

Interested candidates must have a Ph.D. and/or an M.D. and have a strong background in molecular biology, genetics, or virology. Bioinformatic and programming skills will be of great benefit.

To Apply:
Please submit a cover letter, curriculum vitae, bibliography, and names of three references to:

Dr. Henry Levin
Eunice Kennedy Shriver National Institute of Child Health and Human Development
National Institutes of Health
Bld 49, room 1C32
Bethesda, MD, 20892

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