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Postdoctoral Fellowship to study Gene Regulation in Innate Immunity

National Institute of Child Health and Human Development, National Institutes of Health , Bethesda, MD and surrounding area

Position Description:
Study innate immune responses to infection and inflammation using mouse models. Examine host cell transcription by single cell transcriptome approaches and genome-wide chromatin analyses. Employs high resolution imaging of macrophages, microglia and vascular cells. This position requires prior experience in mouse genetics (such as genotyping), basic immunology (including flow cytometry), and molecular genetics (e. g., cloning, PCR).

We investigate transcription factor mutations discovered in patients with infection/inflammatory diseases, and collaborate with clinical research labs in the NIH. We also study mutations of chromatin regulators associated with innate immunity disorders. Our interests have been IRF and STAT family of transcription factors, chromatin regulators with bromodomains and variant histone H3.3.

The laboratory is part of Division of Developmental Biology of the National Institute of Child health and Human Development, NIH. It is in the Bethesda main campus. It is furnished with the equipment and services (including IT services, deep sequencing/data analysis, microscopy) necessary for laboratory research, and has immediate access to the animal facility. The P.I is an established scientist with broad knowledge and experience in cytokines and gene regulation. Beside P.I, the laboratory is composed of two senior scientists, several post-doctoral fellows and a post-bac fellow. There are active collaborations with other laboratories within and outside NIH, making the laboratory an dynamic and exciting place.

Qualifications:
Candidates should have received a Ph. D or M.D (or both) within the past five years.

To Apply:
Please send a CV (with bibliography and references) and a brief narrative on past experience, research interest and future goals to Keiko Ozato at ozatok@nih.gov. The narrative should be concise (less than two paragraphs). Application deadline: December, 2018

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