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Signal Transduction

Clinical Center, Bethesda, MD and surrounding area

Position Description:
Postdoctoral position available immediately to study intracellular signal transduction regulated by the proteins IQGAP1 and calmodulin and their roles in cancer and diabetes. The scaffold protein IQGAP1 forms complexes with heterogeneous binding partners to modulate numerous processes, including migration, adhesion and intracellular signaling. Calmodulin, a ubiquitous protein involved in diverse Ca2+-dependent cellular processes, has important roles in cell-cycle progression, proliferation, cell movement, smooth muscle contraction and Ca2+ homeostasis. The research integrates a diverse array of cell biology, biochemistry and molecular biology techniques to elucidate the functions of Ca2+/calmodulin, IQGAP1, and their binding proteins.

For additional information, see

Strong background in biochemistry, molecular biology or cell biology is required and a Ph.D. within the last three years.

To Apply:
Please send CV and the names of at least three references (with telephone numbers) via email to or via post to:
Dr. David B. Sacks
Senior Investigator
NIH, 10/2C306
10 Center Drive
MD 20892
Ph: 301-496-3386; Fax: 301-402-1885

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