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Epigenetics/Systems Biology Postdoctoral Researcher

National Heart, Lung, and Blood Institute , Bethesda, MD and surrounding area

Position Description:

The National Heart, Lung, and Blood Institute (NHLBI), a major component of the National Institutes of Health (NIH), Department of Health and Human Services has an opening for an Epigenetics & Systems Biology postdoctoral researcher to study immune memory, cellular differentiation, and pathological conditions using genomics, epigenomics and systems biology approaches. Our laboratory has developed the ChIP-Seq, MNase-Seq, single-cell DNase-seq, and 3e Hi-C techniques to analyze genome-wide distribution of chromatin modifications and DNA-binding factors (Cell, 2007; Cell, 2008; Cell 2009; Cell 2012; Nature 2015; Mol Cell 2017; Nat. Immunol. 2017). More recently, we have developed the Trac-looping technique to analyze genome-wide promoter-enhancer interaction, chromatin accessibility and chromatin folding in one single assay (Nature Methods, 2018) and single-cell MNase-seq technique to map genome-wide nucleosome organization in single-cells (Nature 2018). Using these powerful techniques, we are studying the contribution of two-dimensional and three-dimensional nuclear structure to normal development and diseases. Future studies will investigate the function and regulation of three-dimensional nuclear structure during differentiation of hematopoietic stem cells to T cells. The incumbent will focus on bench work or computation work or both depending on previous training and expertise. Opportunities for extensive collaborations with the research communities are available.

Qualifications:

The ideal candidate must have a Ph.D. in Molecular Biology or Biochemistry or computational biology with a strong record of publication. The candidate must have received a Ph.D. within the past three years.

The candidate will be supported with an excellent intramural NIH fellowship in a stimulating and interactive research environment at NIH. Salary is commensurate with research experience and accomplishments. 

To Apply:

Send curriculum vitae and names and addresses of three references to:

Keji Zhao, Ph.D.
Director and Senior Investigator
Systems Biology Center
Division of Intramural Research
National Hear Lung and Blood Institute, NIH
Bldg.10, Rm.7B05
9000 Rockville Pike, Bethesda
MD 20892-1674
E-mail: zhaok@nhlbi.nih.gov

DHHS/NIH is an Equal Opportunity Employer