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Signaling at the Intersection of Development, Stem Cells and Cancer

National Cancer Institute, Bethesda, MD and surrounding area

Position Description:

We seek highly motivated Postdoctoral Fellows interested in developing independent research projects in the area of cell signaling at the intersection of development, stem cells and cancer. Candidates will join the group of Dr. Andres Lebensohn, an Earl Stadtman Principal Investigator in the Laboratory of Cellular and Molecular Biology (LCMB) at the Center for Cancer Research (CCR) of the National Cancer Institute, NIH. We combine functional genomics, genetics, cell biology and biochemistry to study how signaling pathways are used, reused and repurposed to drive the myriad different cellular processes that give rise to tissues and organs during embryonic development, and maintain them in adult life. A major focus of the lab is on WNT signaling, a fundamental pathway that orchestrates embryonic patterning and morphogenesis, and promotes adult tissue renewal and regeneration. We use powerful genetic screens in human cells to discover new regulatory mechanisms, and probe their molecular underpinning through biochemistry and cell biology to understand how they enable the pathway to generate distinct physiological outcomes. Based on this understanding, we hope to devise more selective therapeutic strategies to target tumors driven by dysregulation of WNT signaling. Descriptions of specific research projects can be found at https://ccr.cancer.gov/Laboratory-of-Cellular-and-Molecular-Biology/andres-m-lebensohn.

The laboratory is located at the NIH Bethesda campus within a vibrant biomedical research community, with access to state-of-the art research facilities and close links to the NIH Clinical Center, winner of the 2011 Lasker-Bloomberg Award for Public Service and one of the leading clinical research hospitals in the world. In the words of Dr. Tom Misteli, Director of the CCR, “Our scientists enjoy complete intellectual freedom and are expected to creatively and innovatively explore the most important questions in the field of cancer research and treatment. We support projects over a long time horizon allowing our investigators to pursue some of the most difficult, high-risk problems in the field and we are always on the lookout for new challenges and the most pressing problems in modern cancer research.” The open lab space, collegial atmosphere and joint weekly seminars shared by the seven groups of the LCMB (https://ccr.cancer.gov/Laboratory-of-Cellular-and-Molecular-Biology) give Fellows a strong support network and plenty of opportunities to present and discuss their research with close peers. A short metro ride to Washington D.C. and the surrounding areas provides Fellows and their families easy access to numerous free museums (https://washington.org/free-things-to-do), excellent culinary choices and many outdoor activities.

Qualifications:

Candidates must have completed a Ph.D. and should be recent graduates or have less than 3 years of postdoctoral experience by the desired start date. Candidates with backgrounds in cell, stem cell, developmental or cancer biology are encouraged to apply. Experience in biochemistry, cell biological techniques, organoid tissue culture or mouse genetics is welcome but not required.

Fellows will have outstanding stipend support, funds for travel to scientific conferences, and full healthcare benefits.

To Apply:

Please send a cover letter describing your research accomplishments and future interests, including your specific interest in this lab, a CV with bibliography and contact information for three references to andres.lebensohn@nih.gov.  Please use the following email subject: Application for Postdoctoral Fellow position.

This position is subject to a background investigation. The NIH is dedicated to building a diverse community in its training and employment programs.