Skip to Content

Assay Development and Screening

National Cancer Institute, Frederick, MD

Position Description:

The Molecular Targets Program (MTP) of the National Cancer Institute’s Center for Cancer Research (NCI’s CCR) has a postdoctoral position available in its Assay Development and Screening Section (ADSS).  The position is for assay development for both primary screening and mechanism of action (MOA) studies on the resulting bioactive compounds obtained from high-throughput screening (HTS) campaigns.  The laboratory’s areas of interest include the design and application of HTS assays around newly discovered cancer-related targets and mechanistic hit follow-up with a special emphasis on naturally occurring small molecules.


The selected candidate must have demonstrated expertise in utilization of cellular biochemical approaches to assay development or the elucidation of MOA of active compounds derived from phenotypic high-throughput screens.  Expertise in one or more of the following areas is desired: cell engineering for assay development, pathway/kinome profiling, high-content imaging assays, expression profiling, protein arrays for binding studies, yeast or mammalian chemical genetic and/or proteomic approaches, and in silico target prediction methods (and follow-up).  Candidates with experience with novel assays that can be developed into high throughput screens, or those with the application of CRISPR to the study of elucidation of signaling pathways, are particularly encouraged to apply. The candidates must have a Ph.D. in biochemistry, cell/molecular biology, or a related discipline from an accredited research institution within the last three years.

The fellowship duration is 5 years based on performance and yearly evaluations. The fellowship is not restricted to U.S. citizens. 

To Apply:

Applicants should submit a cover letter, CV with bibliography, and three letters of reference to  More information about the Molecular Targets Program is available here:

This position is subject to a background investigation. The NIH is dedicated to building a diverse community in its training and employment programs; underrepresented minority candidates are encouraged to apply. DHHS, NIH, and NCI are Equal Opportunity Employers.