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Discovery Research Focused on Colorectal Cancer

National Cancer Institute, Bethesda, MD and surrounding area

Position Description:

We are searching for a highly motivated and creative postdoctoral fellow interested in translational research related to "colorectal cancer development and clonal evolution". The focus of this research is on the molecular mechanisms that underlie physiologic cell-to-cell communication within the microenvironment of the intestinal crypt and how disruption of such interplay contributes to intestinal stem cells evolution into cancer cells. This research will be carried out in an exciting environment of creative, dedicated and successful scientists.


The candidate should have evidence of excellent training and productivity, should demonstrate genuine interest in contributing to advances in cancer research and should be able to communicate effectively in writing and verbally. A molecular biology and cell biology background is desirable. The candidate should possess experience in: molecular biology and biochemistry, including construction of lentiviral expression systems, CRISPR-Cas9 gene editing systems, transient and stable gene expression/silencing, PAGE and immunoblotting, quantitative PCR, luciferase-based promoter analysis, chIP assays and analysis of signaling pathways; cell biology, including cell separation, cell-based functional studies, FACS analysis, immunostaining, confocal microscopy; mouse models of cancer, including maintenance of mouse colonies, derivation of mouse strains of interest, handling of mice for cancer-related in vivo experiments, mouse injections, blood drawing, tissue procurement, genotyping and statistical analyses for design and evaluation of pre-clinical cancer models.

The position is located in the Molecular and Cell Biology Section (Dr. G. Tosato) of the Laboratory of Cellular Oncology, CCR/NCI/NIH.

To Apply:

Please submit the following: CV and publication list; a list of References; a statement of interest and employment goals.

Submit information to: (preferably) or mail to

Dr. G. Tosato
Building 37/room 4124
Bethesda, MD 20892

This position is subject to a background investigation. The NIH is dedicated to building a diverse community in its training and employment programs.