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Epigenetic, Genetic, and Environmental Epidemiology of Respiratory and Allergic Health Across the Life-Course

National Institute of Environmental Health Sciences, Research Triangle Park, NC

Position Description:

A postdoctoral position is available, in the Epidemiology Branch at NIEHS/NIH, under the direction of Stephanie J. London, MD, DrPH (www.niehs.nih.gov/research/atniehs/labs/epi/pi/genetics). Dr. London’s research program investigates the impact of environmental exposures on DNA methylation at birth and in adulthood, as well as the interplay between  environmental exposures, epigenetic changes, and genetic variation in relation to respiratory and allergic outcomes  across the life-course.

Current work includes studies of childhood and adult asthma and allergic disease, pulmonary function, and chronic obstructive pulmonary disease. We consider the role of early life and current exposure in these conditions as well as the role of genetics and epigenetics using genome wide approaches. Much of this work takes a collaborative approach in consortia including Pregnancy and Childhood Epigenetics (PACE) and the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE). Work in the PACE Consortium examines the impact of in utero exposures on methylation patterns at birth as well as the impact of methylation at birth on childhood outcomes. Another project is a study of adult asthma among farmers and spouses nested within an agricultural cohort: data collected on over 3,000 individuals include farm and nonfarm exposures, pulmonary function, objective measures of allergy, genome wide genotyping and methylation data (Illumina EPIC chip) and on a large subset, dust microbiota assessed by 16S sequencing. Applicants can work on more than one of these studies. Postdoctoral fellows are encouraged to use these resources to develop new projects that can form the basis for transition to independence funding.

Qualifications:

Candidates must have a doctoral degree (PhD or equivalent) in epidemiology, biostatistics, bioinformatics, genetics, or a related field. Applicants must have extensive experience with epidemiologic or statistical data analysis. Experience with analysis of high dimensional genetic or epigenetic data is a plus but not required.

Postdoctoral fellows are encouraged to take advantage of the rich training and career development opportunities offered at NIEHS and neighboring universities. Former trainees have gone on to positions in academia, government, and industry.

To Apply:

Please email cover letter, curriculum vitae including list of publications in peer-reviewed journals, and the names, phone numbers, and email addresses of three people who could provide letters of reference to: Stephanie J. London, M.D., Dr.P.H. london2@niehs.nih.gov.

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