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Organic and Medicinal Chemistry

National Institute on Drug Abuse , Bethesda, MD and surrounding area

Position Description:

A postdoctoral position is available for an organic chemist to work on multi-step synthesis of mostly nitrogenous small molecules on a multigram scale in the Drug Design and Synthesis Section, National Institute on Drug Abuse (NIDA), 9800 Medical Center Drive, Rockville, Maryland. Our major research direction is the elucidation of the structure and function of neurotransmitter systems in the mammalian central nervous system (CNS) in normal, drug-altered, and pathological states and the molecular mechanism of action of CNS active drugs. Organic/medicinal chemistry is the foundation of the multidisciplinary approach utilized in these studies that requires the rational design and chemical synthesis of novel agonists, antagonists, imaging agents, affinity ligands, and other drugs for particular applications. For more information, please visit:


Candidates should have or be very close to obtaining a Ph.D. and have less than two years of postdoctoral experience, demonstrated experience in synthetic chemistry, and an ability for independent research. Interest in the chemical synthesis of complex organic molecules, optical resolution of racemates, and crystallization is required, as well as the desire to collaborate with colleagues in various pharmacological and other diverse scientific disciplines. The successful candidate should possess excellent interpersonal and organizational skills, and stellar communication skills with fluency in both spoken and written English. 

To Apply:

Qualified individuals should send a cover letter with a brief description of goals and interest, curriculum vitae, bibliography, and contact information for three references (including the current supervisor) to:

Mariena Mattson

Lab Manager
Drug Design and Synthesis Section
Molecular Targets and Medications Discovery Branch
9800 Medical Center Drive, Rm 239A
Bethesda, Maryland 20892-3373

The NIH is dedicated to building a diverse community in its training and employment programs. This position is subject to a background investigation.