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In Vivo Microscopy to Understand Cortical Function

National Institute of Mental Health/National Institute of Biomedical Imaging and Bioengineering, Bethesda, MD and surrounding area

Position Description:

The National Institute of Mental Health (NIMH) and National Institute of Biomedical Imaging and Bioengineering (NIBIB), major research components of the National Institutes of Health (NIH), and the Department of Health and Human Services (DHHS), are seeking exceptional candidates for a Post-Doctoral Fellow position in the Intramural Research Program (IRP), in the laboratories of Dr. Mark Histed and Dr. Hari Shroff.

The position is part of a a BRAIN Initiative-funded project using single-cell (two-photon) optogenetics to study cortical computation. The focus of this position is on development of two-photon optical instruments for neuroscience work, with opportunities to work on super-resolution imaging, image analysis, or projects in systems neuroscience and in vivo brain function depending on the interest and experience of the candidate.

The Histed group seeks to understand sensory representations in mouse cortex and how they are used in behavioral decisions.   The group has experience in a variety of experimental approaches (e.g. 2-photon imaging, in vivo optogenetics, multi-site silicon arrays to record from large neuronal populations) and also collaborates with theoreticians to understand how recurrent cortical networks transform inputs to create computations.  The Shroff group develops new imaging tools to study fast 3D cellular processes, and  advances the state of the art in methods for super-resolution microscopy and single molecule fluorescence.


The ideal candidate will have a PhD degree in neuroscience, physics, engineering, or related discipline, some background in neuroscience, and a demonstrated ability to work in a multidisciplinary team. Useful experience: imaging, in vivo physiology, building optical systems, neurotheory, and/or programming skills (e.g. in Python) for data analysis and/or experiment control. Applicants with masters’ degrees and/or with industry experience in engineering may also be considered. We are seeking a highly motivated individual who has experience working with others and has a demonstrated record of productivity and success in scientific and/or engineering projects.

To Apply:

Salary will be commensurate with education and experience. Applicants are invited to submit a curriculum vitae including publication list, a maximum one-page summary of research interests, and names and contact details of three referees to Dr. Mark Histed by email at

The National Institutes of Health is an equal opportunity employer. The NIH is dedicated to building a diverse community in its training and employment programs.