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Immune Mechanisms of Sepsis and Severe Infection

Clinical Center, NIH, Bethesda, MD and surrounding area

Position Description:

Sepsis is a syndrome of life threatening organ dysfunction in the context of an infection and it is a leading cause of critical illness and admissions to the intensive care unit. Despite decades of research and new therapeutic approaches, treatment options for sepsis remain limited to antibiotics and supportive measures and mortality continues to be unacceptably high. Concepts surrounding the immune pathogenesis of sepsis have evolved over the years leading to immunomodulatory therapies, none of which have shown benefit in clinical trials. It is increasingly evident that variables likely to influence the efficacy of therapies in sepsis include type, route, and severity of infection, time of infection, and underlying clinical characteristics, among others. However, the effect of these variables on immune responses and therefore the feasibility of immune modulation in different patient populations has not been well studied in humans.

Our lab is interested in understanding the effects of these variables on immune parameters in sepsis by making use of human models of inflammation and small animal models of sepsis. Recent emphasis has been on the characterization of the serum proteome in humans following intravenous endotoxin administration, of pulmonary immune cells in human lung lavage and blood following endobronchial endotoxin challenge, as well as elucidation of checkpoint pathways in mouse models of sepsis due to pneumonia.

Qualifications:

Applicants must have the following: an MD or a PhD in the Biological Sciences, with an interest in research related to the immunological basis of sepsis. Qualified candidates should have direct experience with many of the following: maintaining and breeding mouse colonies, handling mice, performing procedures on mice (such as injections, intratracheal inoculations), isolation of blood and tissues from mice, processing of mouse tissue for immune cell isolation, cell culture, bacterial culture. Expertise in flow cytometry and a strong background in immunology are required.

To Apply:

Please send a cover letter, a CV including recent publications, and the names and contact information for three references to Parizad Torabi-Parizi, Tenure-track Investigator at torabiparizip@cc.nih.gov. Further information about our group can be found at: https://clinicalcenter.nih.gov/meet-our-doctors/ptorabiparizi.html.

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