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Neuro-Oncology

National Cancer Institute, Bethesda, MD and surrounding area

Position Description:

The Neuro-Oncology Branch (NOB), National Cancer Institute (NCI) of the National Institutes of Health (NIH) is seeking outstanding postdoctoral candidates for laboratory research related to brain tumors.  NOB is comprised of a multidisciplinary team of physicians, healthcare providers, and scientists who are dedicated to developing new therapies and improving outcomes for patients with primary brain and spinal cord tumors.

One postdoctoral position is available in the Molecular and Cell Biology (MCB) Section of the NOB laboratory in its exciting translational, interdisciplinary research team.  NOB seeks creative and bright individuals who have a keen interest in making a substantial contribution to the understanding of brain tumor biology.  The MCB employs translational techniques to examine the changes in molecular signaling associated with brain tumor development, progression, and drug resistance.  Using clinical specimens, the research team is investigating the mechanistic basis that drives development of disease phenotypes and malignancy.  Ongoing efforts also include studying the role of transcriptional factors in governing cancer malignancy as well as designing novel in vitro/in vivo models for tumor malignant phenotype. Currently our team is focused on the discoveries of cancer biology and epigenetic regulation in isocitrate dehydrogenase (IDH1/2)-mutated malignancies, seeking for future therapeutic approaches for this disease cluster.

Qualifications:

Successful candidates should:

  1. have a strong research background in cancer biology, and especially the use of molecular/cellular approaches to investigate cancer biology and malignant phenotype is strongly encouraged,
  2. have the ability to conduct semi-independent research and function as part of an interdisciplinary team,
  3. have direct experience with many of the following laboratory techniques: cell culture, cell transfection, ELISA, Western blotting, protein complex profiling, chromatin immunoprecipitation (ChIP), Sanger Sequencing, ChIP-Seq, PCR, DNA cloning and subcloning, and site directed mutagenesis,
  4. have expertise in confocal microscopy, flow cytometry and experimental mouse xenograft models, and
  5. possess good communications skills and be fluent in both spoken and written English. 

Applicants should have a Ph.D. degree, preferably in biochemistry, molecular biology, genetics, or related field, be near completion of degree requirements, and have no more than three years of postdoctoral research experience.

To Apply:

Please email curriculum vitae, statement of research interests, and three letters of reference to the attention of:  Chunzhang Yang, Ph.D., Neuro-Oncology Branch, National Cancer Institute, 37 Convent Drive, Room 1142E, Bethesda, MD 20892 at chunzhang.yang@nih.gov.

The National Institutes of Health is an equal opportunity employer. The NIH is dedicated to building a diverse community in its training and employment programs.