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Research Fellow - Functional Modeling of Human Disease

National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC

Position Description:

The Pediatric Neuroendocrinology Group at the National Institute of Environmental Health Sciences (NIEHS), Research Triangle Park, North Carolina is seeking a talented Research Fellow.  We recently demonstrated that missense mutations in the gene SMCHD1 (Structural maintenance of chromosomes flexible hinge domain-containing protein 1) are the main genetic driver of congenital arhinia, an extremely rare craniofacial malformation characterized by the complete absence of the external nose and often associated with ocular and reproductive defects (Shaw et al. Nature Genetics 2017).  SMCHD1 is a master epigenetic repressor that silences both X-linked and autosomal genes and plays a role in DNA damage repair. To understand the functional consequences of these mutations and to identify modifier loci, we are using a multi-pronged approach that includes genomic, proteomic, and molecular biology studies in patient-derived neural stem cells, transgenic mouse modeling, and structural biology.

Research Fellows are hired as full-time NIH employees and are eligible for federal employee benefits. This posting is for a one-year position with the intent to renew in 1-year increments for a maximum length of 8 years. Competitive salaries are determined by educational degree(s) and number of years of relevant postdoctoral experience.

NIEHS is located in Research Triangle Park, North Carolina, between Raleigh, Durham, and Chapel Hill, and is a ~15 minute drive to Duke University, the University of North Carolina-Chapel Hill, and North Carolina State University.  NIEHS provides a stimulating environment and excellent opportunities for young scientists to develop their research careers.

Qualifications:

Applicants must have a doctoral level degree with no more than five years of postdoctoral research. Experience and/or interest in stem cell biology, mouse embryology, biochemistry, genetics, and epigenetics is strongly recommended. Expertise in protein expression in bacterial and mammalian cells, protein purification, and structural or functional studies of oligomeric protein complexes is highly desirable. Applicants should be highly motivated, capable of conducting research with limited supervision, and have strong oral and written communication skills.

To Apply:

Please email a cover letter, curriculum vitae with list of publications in peer-reviewed journals, and the names and contact information of 3 references to: Natalie Shaw, MD, MMSc, Natalie.shaw@nih.gov.

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