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Functional Genomics, Genetic Susceptibility to Lung Cancer and Melanoma

Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD and surrounding area

Position Description:

A new research group in the Laboratory of Translational Genomics (LTG) under the Division of Cancer Epidemiology and Genetics (DCEG) of the National Cancer Institute is seeking candidates for postdoctoral positions.

The new research program will study genetic susceptibility to common cancers including melanoma and lung cancer, focusing on mechanistic understanding of genomic data from epidemiological studies such as those from genome-wide association studies (GWAS). The goal is to identify genes and molecular pathways through which heritable genetic variants confer increased cancer risk and eventually, improve cancer prevention and therapy. In parallel, fundamental questions of how gene expression is regulated through heritable variants in cell-type specific manner will be addressed. The group will also explore deconvoluting genetic and non-genetic risk factors contributing to lung cancer in never-smokers using the data generated through a large-scale genomic/epidemiologic study (https://dceg.cancer.gov/research/cancer-types/lung/sherlock-lung-study).

The position offers an opportunity to explore molecular mechanisms of lung cancer and melanoma susceptibility by identifying genes and pathways that contribute to risk, identified from GWAS data. A wide range of functional genomics approaches will be adopted including eQTL, MPRA, RNAseq, Hi-C, and CRISPR-screening. Conventional approaches of molecular genetics and cancer biology will also be adopted to functionally characterize the tumor-promoting potential of identified genes in cell-based systems. The focus of this position will be leading/co-leading international collaborative projects, designing and performing experiments while working closely with multidisciplinary experts such as bioinformaticians, clinicians, and statisticians. Opportunities for learning computational skills and statistical genetics as well as mentoring postbacs or summer students will be available based on interest.

LTG provides a unique collegial environment with multiple groups studying different cancers while collaboratively developing/adopting cutting-edge techniques and methodologies (https://dceg.cancer.gov/about/organization/programs-hgp/ltg). DCEG and NIH provide multiple channels of career development and well-being support to postdoctoral fellows.

For more information about this position, please contact: Jiyeon Choi, Ph.D, Email: jiyeon.choi2@nih.gov.

Qualifications:

Candidates must have completed or will soon complete a Ph.D. or equivalent degree with an emphasis in Molecular Biology, Cell Biology, Cancer Biology, Human or Mouse Genetics, Population Genetics, or related areas within the past 5 years. A demonstrated ability to work in a multidisciplinary and diverse team and clear communication skills will be favored. Salary will be determined based on NCI stipend schedule for postdoctoral fellows.

To Apply:

Please send a cover letter, curriculum vitae including bibliography, and the names/contact information of three references to jiyeon.choi2@nih.gov.

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