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Regenerative Therapies for Inherited Blood Disorders

National Heart, Lung, and Blood Institute, Bethesda, MD and surrounding area

Position Description:

The Division of Intramural Research (DIR) of the National Heart, Lung, and Blood Institute (NHLBI) is seeking to recruit an outstanding post-doctoral fellow to participate in the research program of the Section for Regenerative Therapies for Inherited Blood Disorders of the Cellular and Molecular Therapeutics Branch (CMTB), led by Dr. Andre Larochelle (https://www.nhlbi.nih.gov/science/regenerative-therapies-inherited-blood-disorders).

This laboratory is investigating novel strategies and stem cell concepts to advance the translational field of regenerative medicine, with a focus on inherited disorders affecting blood-forming hematopoietic stem cells (HSCs), including: 1) Gene therapy: Genetic correction of adult HSCs using CRISPR/Cas and viral vector technologies, and ex vivo expansion of genetically corrected HSCs; 2) Cell Therapy: Derivation of engraftable HSCs from genetically corrected induced pluripotent stem cells (iPSCs); 3) Drug Therapy: Expansion of adult HSCs in vivo using the small molecule eltrombopag, and high-throughput screens for alternative small molecules. There are strong interactions with a wide range of dynamic, independent research groups, and the position offers exceptional opportunities for interdisciplinary collaboration within and outside of the NIH.

Qualifications:

The successful candidates should have a strong track record of achievement, expertise, creativity, passion and experience in laboratory research. Applicants must have:

  • Ph.D. or M.D./Ph.D., within five years of degree conferral;
  • Laboratory skills in iPSC culture, CRISPR genome editing, animal handling, and other general molecular/cellular biology;
  • Verbal and written proficiency in English, as demonstrated by peer-reviewed publications, and local, national or international presentations;
  • Demonstrated ability to work efficiently both independently and within a multi-disciplinary team. Excellent organization and documentation skills; all laboratory research notes and data are maintained electronically;
  • Willingness to mentor students or other trainees;
  • Appointees may be US citizens, resident aliens, or non-resident aliens with or eligible to obtain a valid employment authorized visa. 

To Apply:

Applications should include a 1-2 page letter of interest, curriculum vitae  with complete bibliography, and contact information for three references (letters not required at first inquiry), to be sent by e-mail to Andre Larochelle, M.D., Ph.D., Cellular and Molecular Therapeutics Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Clinical Research Center, Room 5-5132, 9000 Rockville Pike, Bethesda, MD 20892 USA; E-mail: larochea@nhlbi.nih.gov. The review of applications will begin on July 15th, 2019. Applications will be accepted until the positions are filled.

HHS and NIH are Equal Opportunity Employers. The NIH is dedicated to building a diverse community in its training and employment programs.