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Cell Signaling at the Interface of Development, Stem Cells and Cancer

National Cancer Institute, Bethesda, MD and surrounding area

Position Description:

We seek highly motivated Postdoctoral Fellows interested in developing independent research projects in the area of cell signaling at the interface of development, stem cells and cancer. Candidates will join the group of Dr. Andres Lebensohn, an Earl Stadtman Principal Investigator in the Laboratory of Cellular and Molecular Biology (LCMB) at the Center for Cancer Research (CCR) of the National Cancer Institute (NCI). We combine functional genomics, CRISPR/Cas9-mediated genome editing, cell biology and biochemistry to study how signaling pathways are used, reused and repurposed to drive the myriad different cellular processes that give rise to tissues and organs during embryonic development and maintain them in adult life. A major focus of the lab is on WNT signaling, a fundamental pathway that orchestrates embryonic patterning and morphogenesis, and promotes stem cell self-renewal and tissue regeneration. We use powerful genetic screens in human cells to discover new regulatory mechanisms. We probe their molecular underpinning through biochemistry and cell biology. We seek to unravel how they generate distinct physiological outcomes using organoid cultures and animal models. Based on this understanding, we hope to devise more selective therapeutic strategies to target tumors driven by dysregulation of WNT signaling. Descriptions of specific research projects can be found at

About the Center for Cancer Research and the Laboratory of Cellular and Molecular Biology:
The CCR is the largest division of the NCI intramural research program, comprising nearly 250 basic and clinical research groups. In the words of Dr. Tom Misteli, director of the CCR, “Our scientists enjoy complete intellectual freedom and are expected to creatively and innovatively explore the most important questions in the field of cancer research and treatment.” The LCMB ( is located at the NIH Bethesda campus within a vibrant biomedical research community. We have access to state-of-the art research facilities and close links to the NIH Clinical Center, one of the leading clinical research hospitals in the world. The open lab space, collegial atmosphere and joint weekly seminars shared by the seven groups of the LCMB give Fellows a strong support network and plenty of opportunities to present and discuss their research with close peers. A short metro ride to Washington D.C. and the surrounding areas provides Fellows and their families access to numerous free museums (, excellent culinary choices and many outdoor activities.


Candidates must have completed a Ph.D. within the past 3 years. At least one first/co-first authored manuscript (published or submitted) is highly recommended. Candidates with backgrounds in cell, stem cell, developmental or cancer biology are encouraged to apply. Experience in small-molecule screening, biochemistry, cell biology, organoid tissue culture or mouse genetics is welcome but not required.

Fellows will have exceptional stipend support for the entire duration of their post-doc, full healthcare benefits and funds for travel to scientific conferences.

To Apply:

Please send the following information to

1) a cover letter describing: A) previous research accomplishments, clearly stating the key findings and significance of your work; B) future interests, explicitly stating why you are interested in my research and which projects inspire you.

2) a CV including bibliography and contact information for three references.

Please use the following email subject: “Application for postdoctoral position”.


This post will be available until July 17, 2020 or until filled.

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