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Gene Regulation of Innate and Adaptive Lymphocytes in Neuroinflammation

National Eye Institute/National Institute of Neurological Disorders and Stroke, Bethesda, MD and surrounding area

Position Description:

A postdoctoral position is available in the Shih lab in Neuro-Immune Regulome Unit at National Eye Institute and National Institute of Neurological Disorders and Stroke in Bethesda, MD. Recently, emerging evidence indicates a role of inflammation in aging and neurodegenerative diseases; however, how pro-inflammatory molecules and immune cells are involved in disease onset and pathogenesis remains largely unknown. Our lab aims to understand the transcriptional networks in gene regulation of lymphocytes and cytokines in diseases of the eye and CNS. Using unbiased genomic approaches including single cell RNA-seq, single cell ATAC-seq, ChIP-seq or Cut&Run, Hi-C and CRISPR-screening, we seek to identify novel regulatory pathways for therapeutic targets. 

This position offers exposure to multidisciplinary and cutting-edge genomic researches and opportunities to collaborate closely with experts in immunology, neurobiology and bioinformatics. The candidates will be leading/co-leading projects, designing experiments for generating high-dimensional data while working closely with collaborators and lab members. Opportunities for training in bioinformatics as well as mentoring postbacs or summer students will be available based on interest.


  • Candidates must hold an M.D./Ph.D. or Ph.D. in immunology, neuroscience, genetics, molecular biology, biochemistry or a related field, within five years of degree being awarded;
  • Must have first authorship on at least one peer-reviewed publication;
  • Must be self-motivated and keen to develop and/or learn cutting-edge technologies and basic programming in R for big data analysis;
  • Experience in animal dissection and cell isolation from CNS are preferred;
  • Experience in ChIP-seq/Cut&Run or Hi-C relevant assays are also preferred;
  • The ability to work as part of a cohesive group is important as we are a highly collaborative lab;
  • Have excellent writing and communication skills.

To Apply:

Interested candidates should send a cover letter, curriculum vitae, bibliography, a paragraph of research statement and contact information of three references to: Han-Yu Shih (


This post will be available until July 20, 2020 or until filled.

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